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Computational Cancer Biology

Part of the SpringerBriefs in Electrical and Computer Engineering Book Series

DOI: 10.1007/978-1-4471-4751-0

ISBN: 978-1-4471-4750-3

Publisher: Springer London - Springer Journals

Nov 23, 2012

Available

The Role of System Theory in Biology

Vidyasagar, Mathukumalli

Pages: 1 –12

[In this chapter we introduce the reader to current methods for generating biological data, including such topics as micro-array (or gene expression) studies, ChIP-seq studies, siRNAs, and micro-RNAs. Special features of biological data that necessitate the development of new algorithms are...
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Analyzing Statistical Significance

Vidyasagar, Mathukumalli

Pages: 13 –29

[In this chapter we review some popular methods for estimating the statistical significance of various conclusions that can be drawn from experimental data. These include the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts}...
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Inferring Gene Interaction Networks

Vidyasagar, Mathukumalli

Pages: 31 –68

[This chapter contains the original research results on the monograph. We study the problem of reverse-engineering context-specific, genome-wide interaction networks from expression data. Two existing classes of methods, namely those based on mutual information and those based on Bayesian...
Available

Some Research Directions

Vidyasagar, Mathukumalli

Pages: 69 –80

[In this final chapter, three different directions for future research are sketched. The first problem is that of harmonizing prior knowledge about gene interaction networks that is scattered throughout the literature with the output of the phixer algorithm. This is formulated as a problem in...

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