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Regression Methods in Biostatistics

Part of the Statistics for Biology and Health Book Series

DOI: 10.1007/978-1-4614-1353-0

ISBN: 978-1-4614-1352-3

Publisher: Springer US - Springer Journals

Jan 17, 2012

1 - 10 of 13 Chapters

Available

Introduction

Vittinghoff, Eric; Glidden, David V.; Shiboski, Stephen C.; McCulloch, Charles E.

Pages: 1 –6

[The book describes a family of statistical techniques that we call multipredictor regression modeling. This family is useful in situations where there are multiple measured factors (also called predictors, covariates, or independent variables) to be related to a single outcome (also called the...
Available

Exploratory and Descriptive Methods

Vittinghoff, Eric; Glidden, David V.; Shiboski, Stephen C.; McCulloch, Charles E.

Pages: 7 –26

[Before beginning any sort of statistical analysis, it is imperative to take a preliminary look at the data with three main goals in mind: first, to check for errors and anomalies; second, to understand the distribution of each of the variables on its own; and third, to begin to understand the...
Available

Basic Statistical Methods

Vittinghoff, Eric; Glidden, David V.; Shiboski, Stephen C.; McCulloch, Charles E.

Pages: 27 –67

[Statistical analyses involving multiple predictors are generalizations of simpler techniques developed for investigating associations between outcomes and single predictors. Although many of these should be familiar from basic statistics courses, we review some of the key ideas and methods here...
Available

Linear Regression

Vittinghoff, Eric; Glidden, David V.; Shiboski, Stephen C.; McCulloch, Charles E.

Pages: 69 –138

[Post-menopausal women who exercise less tend to have lower bone mineral density (BMD), putting them at increased risk for fractures. But they also tend to be older, frailer, and heavier, which may explain the association between exercise and BMD. People whose diet is high fat on average have...
Available

Logistic Regression

Vittinghoff, Eric; Glidden, David V.; Shiboski, Stephen C.; McCulloch, Charles E.

Pages: 139 –202

[Patients testing positive for a sexually transmitted disease at a clinic are compared to patients with negative tests to investigate the effectiveness of a new barrier contraceptive. One-month mortality following coronary artery bypass graft surgery is compared in groups of patients receiving...
Available

Survival Analysis

Vittinghoff, Eric; Glidden, David V.; Shiboski, Stephen C.; McCulloch, Charles E.

Pages: 203 –259

[Children receiving a kidney transplant may be followed to identify predictors of mortality. Specifically, is mortality risk lower in recipients of kidneys obtained from a living donor? If so, is this effect explained by the time the transplanted kidney is in transport or how well the donor and...
Available

Repeated Measures and Longitudinal Data Analysis

Vittinghoff, Eric; Glidden, David V.; Shiboski, Stephen C.; McCulloch, Charles E.

Pages: 261 –308

[Knee radiographs are taken yearly in order to understand the onset of osteoarthritis. Troponin (which is an indicator of heart damage) is measured from blood samples 1, 3, and 6 days following a brain hemorrhage. Groups of patients in a urinary incontinence trial are assembled from different...
Available

Generalized Linear Models

Vittinghoff, Eric; Glidden, David V.; Shiboski, Stephen C.; McCulloch, Charles E.

Pages: 309 –330

[A new program for depression is instituted in the hopes of reducing the number of visits each patient makes to the emergency room in the year following treatment. Predictors include (among many others) treatment (yes/no), race, and drug and alcohol usage indices. A common and minimally invasive...
Available

Strengthening Causal Inference

Vittinghoff, Eric; Glidden, David V.; Shiboski, Stephen C.; McCulloch, Charles E.

Pages: 331 –394

[In Chaps. 4–8, we showed how multi-predictor regression can be used to control for confounding in observational data, with the purpose of estimating the independent association of an exposure with an outcome. The cautious language of associations notwithstanding, the underlying purpose is often...
Available

Predictor Selection

Vittinghoff, Eric; Glidden, David V.; Shiboski, Stephen C.; McCulloch, Charles E.

Pages: 395 –429

[Walter et al. (2001) developed a model to identify older adults at high risk of death in the first year after hospitalization, using data collected for 2,922 patients discharged from two hospitals in Ohio. Potential predictors included demographics, activities of daily living (ADLs), the...

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