1 - 6 of 6 Chapters
[In recent decades, we in academia have focused on advancing scientific understanding through basic research and counted on the biopharmaceutical industry to translate promising discoveries into new therapeutics. Given the recent developments, however, this paradigm needs to change....
[In any drug discovery and development effort, we must accomplish a number of critical steps to arrive at a compound that is safe and efficacious, and also exhibits the complex array of desired drug-like behaviors that warrants advancement to the clinic. These tasks include target identification...
[Transitioning from preclinical to clinical development can be both an exhilarating and a sobering experience. Presumably, our drug has passed through a rigorous battery of preclinical testing and appears to have the desired safety profile and pharmacologic characteristics for advancement to...
[Most academic institutions require their researchers and clinicians to assign all intellectual property rights to the institution. The university technology transfer office (TTO) then becomes the clearinghouse for filing patents and granting licenses for new inventions. Navigating this process...
[As academic researchers, some of us may be interested in forming start-up companies to develop and market the drugs that are based on our research. Others may be happy to license our technology and findings to an existing company. Knowing how to evaluate potential drug markets and effectively...
[During the twentieth century, advances in drug therapy came fast and furious, resulting in the cure of many previously fatal diseases such as pneumonia, tuberculosis, and testicular cancer. Treatments for more chronic diseases (e.g., asthma, heart failure, hypertension, and diabetes mellitus)...
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