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Analytical Chemistry

Subject Areas: Analytical Chemistry
Publisher: American Chemical Society - American Chemical Society
ISSN: 1520-6882
SJR: 343

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Journal Article

Protein-Directed Au(0)-Rich Gold Nanoclusters as Ratiometric Luminescence Sensors for Auric Ions via Comproportionation-Induced Emission Enhancement

Sun, Yafang; Zhou, Ziping; Peng, Peiwen; Shu, Tong; Su, Lei; Zhang, Xueji

2023 Analytical Chemistry

doi:10.1021/acs.analchem.2c04718 pmid:36971524

Gold nanoclusters (Au NCs) are widely used as fluorescent probes in biomedical sensing and imaging due to their versatile optical properties and low cytotoxicity. Surface engineering of gold nanoclusters (Au NCs) aims to design a surface with versatile physicochemical performances, but previous...
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Journal Article

Online Fully Automated System for Hydrogen/Deuterium-Exchange Mass Spectrometry with Millisecond Time Resolution

Kish, Monika; Smith, Victoria; Lethbridge, Natasha; Cole, Lindsay; Bond, Nicholas. J.; Phillips, Jonathan J.

2023 Analytical Chemistry

doi:10.1021/acs.analchem.2c05310 pmid:36896500

Amide hydrogen/deuterium-exchange mass spectrometry (HDX-MS) is a powerful tool for analyzing the conformational dynamics of proteins in a solution. Current conventional methods have a measurement limit starting from several seconds and are solely reliant on the speed of manual pipetting or a...
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Journal Article

Highly Efficient Signal On/Off Electrochemiluminescence Gel Aptasensor Based on a Controlled Release Strategy for the Sensitive Detection of Prostate Specific Antigen

Zhao, Lu; Song, Xianzhen; Fan, Dawei; Liu, Xuejing; Wang, Huan; Wei, Qin; Wu, Dan

2023 Analytical Chemistry

doi:10.1021/acs.analchem.2c05655 pmid:36952259

The controlled release strategy can make the constructed sensor have the function of self-on/off, which has an obvious effect on improving the sensitivity in immunoassays. Metal organic gels (MOGs) are the most noteworthy. They are materials with ultrahigh surface area, highly dispersed atomical...
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Journal Article

Capillary Flow-Driven Microfluidics Combined with a Paper Device for Fast User-Friendly Detection of Heavy Metals in Water

Aryal, Prakash; Brack, Eric; Alexander, Todd; Henry, Charles S.

2023 Analytical Chemistry

doi:10.1021/acs.analchem.3c00378 pmid:36952654

Human exposure to heavy metals is a concerning global problem because of its detrimental effect on our health and ecosystem. Assessing the levels of these metals is cost- and labor-intensive and nonuser friendly because current analysis approaches typically rely on heavy instrumentations like...
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Journal Article

Ultrasensitive Hybridization Chain Reaction-Assisted Multisite Exonuclease III Amplification Strategy Combined with a Direct Quantitative Fluorescence Lateral Flow Technique for Multiple Bacterial 16S rRNA Detection

Peng, Xin; Mei, Xuecui; Yang, Jiao; Liu, Jiang; Li, Yingchun

2023 Analytical Chemistry

doi:10.1021/acs.analchem.3c00270 pmid:36946074

Accurate and in-time detection of bacteria conduces to preventing their rapid spread around the environment, while a nucleic acid test (NAT) is a powerful tool for early diagnosis of pathogens. Herein, we propose a hybridization chain reaction (HCR)-mediated multisite exonuclease III (Exo-III)...
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Journal Article

Broad-Specificity Screening of Pyrethroids Enabled by the Catalytic Function of Human Serum Albumin on Coumarin Hydrolysis

Liang, Zengqiang; Sun, Yuanqiang; Zeng, Huajin; Qin, Haimei; Yang, Ran; Qu, Lingbo; Zhang, Ke; Li, Zhaohui

2023 Analytical Chemistry

doi:10.1021/acs.analchem.2c05556 pmid:36952638

Sensing systems based on cholinesterase and carboxylesterase coupled with different transduction technologies have emerged for pesticide screening owing to their simple operation, fast response, and suitability for on-site analysis. However, the broad spectrum and specificity screening of...
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Journal Article

Light-Controlled Particle Enrichment Patterns in Droplets

Li, Dongliang; Li, Wei; Chen, Rong; Zhu, Xun; Ye, Dingding; Yang, Yang; Liao, Qiang

2023 Analytical Chemistry

doi:10.1021/acs.analchem.3c00763 pmid:36960743

Precision manipulation of particle-enrichment patterns in droplets is challenging but important in biochemical analysis and clinical diagnosis. Herein, a light strategy for precisely manipulating particle enrichment patterns is reported. Focused laser irradiation to the droplet induces a...
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Journal Article

Rational Construction of a Novel Bioluminescent Substrate for Sensing the Tumor-Associated Hydrolase Notum

Song, Lilin; Sun, Mengru; Shi, Jinhui; Tian, Zhenhao; Song, Yuqing; Liu, Huixin; Zhao, Shanshan; Yin, Heng; Ge, Guangbo

2023 Analytical Chemistry

doi:10.1021/acs.analchem.3c00633 pmid:36962078

Notum, one of the key serine hydrolases in mammals, hydrolyzes the palmitoleoyl moieties of many important proteins and modulates multiple signaling pathways including Wnt/β-catenin signaling. Notum is tightly associated with multiple human diseases, but the reliable and practical tools for...
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Journal Article

Nucleic Acid Amplification by Template-Dominated Click Chemistry for Ultrasensitive DNA/RNA Detection on an Electrochemical Readout Platform

Yang, Liang-Yong; Xu, Xiong-Wei; Lin, Yan; Ye, Chen-Liu; Liu, Wei-Qiang; Liu, Zhou-Jie; Zhong, Guang-Xian; Xu, Yan-Fang; Lin, Xin-Hua; Chen, Jin-Yuan

2023 Analytical Chemistry

doi:10.1021/acs.analchem.2c05421

As an enzyme-free exponential nucleic acid amplification method, the click chemistry-mediated ligation chain reaction (ccLCR) has shown great prospects in the molecular diagnosis. However, the current optics-based ccLCR is challenged by remarkable nonspecific amplification, severely hindering...
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Journal Article

Multicolor Adjustable B–N Molecular Switches: Simple, Efficient, Portable, and Visual Identification of Butanol Isomers

Sun, Yitong; Ding, Huangting; Tang, Meng; Wen, Jingyi; Yue, Shiwen; Peng, Ye; Zheng, Liyan; Shi, Yonggang; Cao, Qiue

2023 Analytical Chemistry

doi:10.1021/acs.analchem.2c05045 pmid:36942711

As intelligent probes, dynamic and controllable molecular switches are useful tools for probing and intervening in life processes. However, the types and properties of molecular switches are still relatively single and often can only make two actions: “off” and “on”. Therefore, the development...

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