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Three traditions of alcoholism are reviewed: a moral model, a disease model, and a public health model. The public health model is emerging as a major paradigmatic shift, supported by substantial empirical data of the past decade. The arena of alcoholism has heretofore included only alcoholics,...
Adult male rats were rendered progressively tolerant to ethanol by daily intragastric administration of doses of 3–6 g/kg body weight. Functional tolerance assessed by the hypothermic effect after injection of a challenge dose of ethanol developed slowly and was demonstrable after 2 weeks of...
A common complication of chronic alcohol abuse is folic acid deficiency, which can result from poor dietary intake and from a direct effect of ethanol on folate metabolism, such as the acute decrease in serum folate levels. Ethanol (4 g/kg body weight) was administered orally to male...
Forty‐five American Indian alcoholics were intensively studied in 1970–1971. In addition to the usual demographic characteristics, research scales included Alcoholism History Scale, Alcohol Withdrawal Scale, Indian Culture Affiliation Scale, Social Competence Scale, Legal Problems Scale,...
The effect of a single dose (2 g/kg, body weight) of ethanol on diamine oxidase activity of the upper gastrointestinal tract was studied in fasted rats. Ethanol given by gastric intubation as a 10%, 20%, or 40% solution caused an early and transient increase in diamine oxidase activity in...
Ethanol was administered as a single p.o. dose (2.88 g kg‐1) to male rats (220–265 g body weight) to give blood alcohol concentrations of 40–50 IDM for the following 3 hr. Controls were given isoenergetic amounts of either sucrose or lipid. Liver protein synthetic rates were measured during a 20...
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