1 - 10 of 17 articles
Background: Alcohol abuse can induce testicular atrophy, but it only occurs in some alcoholics. Alcohol dehydrogenase (ADH) is located principally on the Leydig cells.
Background: Human gastric mucosa contains three alcohol dehydrogenase (ADH) isozymes (classes I, III, and IV). Various factors such as Helicobacter pylori infection, sex, age, and the part of the stomach involved have been suggested to affect alcohol dehydrogenase activities, although these...
Background: Although a number of studies on traditional eastern or Chinese medicine, such as acupuncture, moxibustion, and herbal drugs, have been reported, few reports describe electroacupuncture (EAC) effects on drug‐ and alcohol‐seeking behaviors in animal models. The purpose of the present...
Background: Studies with gut sterilization and Kupffer cell inactivation support the hypothesis that endotoxin and Kupffer cells are involved in mechanisms of alcohol‐induced liver injury. Recently, we found that Kupffer cells isolated from rats treated only once with ethanol were sensitized to...
Aims: We examined the relationships of ALDH2 and CYP2E1 genotypes on drinking behavior and the incidence of alcoholic liver disease in Japanese male workers.
All‐trans retinoic acid formation from all‐trans retinol (vitamin A) in the human gastric mucosa was studied. When all‐trans retinol and the human gastric mucosa were incubated together, all‐trans retinoic acid was formed in the presence of nicotinamide adenine dinucleotide (NAD). When the NAD...
Background: There are six histological classifications of alcoholic liver disease (ALD) in Japan. However, it is unclear whether all cases of the disease conform to these criteria. This study investigated the clinicopathological features of eight histologically unusual cases of ALD.
Serum variants of des‐γ‐carboxy prothrombin (DCP) recognized by two different monoclonal antibodies, 19B7 and MU‐3, were measured in patients with alcoholic liver disease (ALD), and the values were compared with those of viral liver disease (VLD) and hepatocellular carcinoma (HCC). In the assay...
Background: Nitric oxide (NO) is a potent mediator of hepatic sinusoidal hemodynamics that is synthesized in the hepatic stellate cells (Ito cells, fat‐storing cells) and affects these cells. NO production may depend on the induction of inducible nitric oxide synthase and on transport of...
Background: Recently, a restriction fragment length polymorphism in the regulatory region of the CYP2E1 gene was identified. It has been suggested that the polymorphism is associated with the elevated activity of the cytochrome P‐450 2E1 (CYP2E1) enzyme in obese or alcoholic subjects. However,...
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