1 - 10 of 22 articles
Background: Those with early‐onset alcoholism may better respond to ondansetron (a 5‐HT3 receptor antagonist) than to selective serotonin reuptake inhibitor (SSRI) treatment, whereas those with late‐onset alcoholism may present the reverse response pattern. Johnson and colleagues proposed a...
Background: The human aldehyde dehydrogenase‐2 promoter contains sites that bind members of the nuclear receptor family, and one (designated FP330–3′) is predicted to bind retinoic acid receptors.
Background: Ethanol modulates the functional activity of α4β2 neuronal nicotinic cholinergic receptors (nAChR) when measured in vitro, but the potential role of α4β2 nAChRs in regulating behavioral effects of ethanol is unknown. Recently, Tritto et al. (Tritto T, Stitzel JA, Marks MJ, Romm E,...
Background: Ethanol is known to acutely inhibit AMPA receptor function, and sensitivity of AMPA receptors to ethanol is dependent on subunit composition in vivo and in vitro. A commonly used in vitro expression system for studying recombinant receptor subunits is the Xenopus laevis oocyte and...
Background: Neuropeptide Y (NPY) is the most abundant and widely distributed peptide in the mammalian central nervous system. Evidence suggests that NPY transmission at Y1 receptors may regulate alcohol self‐administration in rodent models. The purpose of the present study was to test the...
Background: C57BL/6 (B6) mice voluntarily consume ethanol. Although preingestive factors might be accountable, the fact that B6 mice voluntarily consume sufficient ethanol to set the conditions for an ethanol‐deprivation effect suggest that post‐ingestive pharmacological induced changes also...
Background: Individual differences in neural circuitry that regulate emotional reactivity may be associated with alcoholism and antisocial personality disorder (ASPD), a common comorbid condition. The emotion‐modulated startle reflex was used to investigate emotional reactivity among...
Background: Neuropeptide Y (NPY) is the most abundant and widely distributed peptide in the mammalian central nervous system and increases feeding behavior at NPY Y1 or Y5 receptor subtypes. Recent pharmacological and mutant mouse data indicate that NPY activity at its receptors can influence...
Background: Studies in humans and animals suggest that those with a genetic predisposition toward high levels of alcohol consumption have decreased pain thresholds. The present study explores this association in rat lines selectively bred for alcohol preference or nonpreference.
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