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Background: The large‐conductance calcium‐activated potassium channel encoded by the slowpoke gene has recently been implicated in the ethanol response. Caenorhabditis elegans carrying mutations in this gene have altered ethanol sensitivity and Drosophila mutant for this gene are unable to...
Background: Previous work found that extracts from the roots of Salvia miltiorrhiza, a Chinese medicinal herb, reduced alcohol intake in selectively bred Sardinian alcohol‐preferring (sP) rats. The present study was designed to evaluate whether miltirone, one of the possible active constituents...
Background: Alcohol misuse is more common in persons with a family history of alcoholism (FH+) than in those with no such history (FH−). Among FH+, behavioral disinhibition and male sex seem to signal the presence of an increased risk.
Background: This study examined the elevated heart rate (HR) response to alcohol intoxication, thought to reflect an increased sensitivity to alcohol‐induced reward, as a potential factor in the increased likelihood of alcohol‐induced aggression.
Background: Topiramate, an anticonvulsant, has been reported to increase the number of abstinent days and decrease craving in alcohol‐dependent individuals. However, the neurobiological basis for topiramate's effect is unknown. To assess topiramate's effect on ethanol's rewarding and...
Background: Neuropeptide Y (NPY) has been implicated in a variety of behaviors including those associated with anxiety and ethanol administration. The current experiment investigated the predictive role of anxiety‐like behaviors in ethanol self‐administration and the relationship of NPY in the...
Background: The relationship between stress and alcohol consumption has been shown in recent research to be more complex than originally thought. Cross‐sectional and short‐term longitudinal studies may not provide adequate data to address subtle but important relationships that impact...
Background: Baclofen, a GABAB agonist, has been found to decrease alcohol craving in humans and to nonselectively decrease ethanol intake in some rodent models. This experiment assessed the effects of repeated administration of baclofen on reinforcer seeking and consumption using the sipper tube...
Background: The purpose of this study was to investigate the effects of chronic ethanol exposure (CEE) and withdrawal on corticostriatal plasticity in rats.
Background: Accumulating evidence indicates that adenosine monophosphate (cAMP)‐dependent protein kinase A (PKA) is involved in the neurobiological responses to ethanol. Previous reports indicate that mice lacking the RIIβ subunit of PKA (RIIβ−/−) voluntarily consume more ethanol than wild‐type...
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