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Background Chronic ethanol (EtOH) administration to experimental animals induces hepatic oxidative stress and up‐regulates mitochondrial biogenesis. The mechanisms by which chronic EtOH up‐regulates mitochondrial biogenesis have not been fully explored. In this work, we hypothesized that...
Background The ADH1B gene has consistently been implicated in problem drinking, but rarely incorporated into gene by environment investigations of alcohol phenotypes. This study examined the joint effects of variation in ADH1B and childhood adversity—a well‐documented risk factor for alcohol...
Background Data from C57BL/6J (B6) × DBA/2J (D2) F2 intercrosses (B6xD2 F2), standard and recombinant inbred strains, and heterogeneous stock mice indicate that a reciprocal (or inverse) genetic relationship exists between alcohol consumption and withdrawal severity. Furthermore, some genetic...
Background Evidence suggests that chronic misuse of alcohol may preferentially affect the integrity of frontal white matter (WM) tracts, which can impact executive functions important to achieve and maintain abstinence. Methods Global and regional WM microstructure was assessed using diffusion...
Background We examined the effects of moderate prenatal alcohol exposure and/or prenatal stress exposure on (D1R) binding in a non human primate model. The dopamine D1R is involved in executive function, and it may play a role in cognitive behavioral deficits associated with prenatal alcohol...
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