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Calcium homeostasis is intimately regulated by protein kinase
phosphorylation cascades that are also involved in the induction and maintenance
of cardiac hypertrophy. In addition, the development of cardiac
hypertrophy has been associated with alteration in the activation of the
Rat neonatal ventricular myocytes exposed to simulated
ischaemia and reperfusion (SI/R) were used as an in vitro model to delineate
the role(s) of extracellular signal–regulated kinase (ERK), p38 and c–Jun NH2–terminal protein kinase (JNK), as well as PKB in apoptosis. Exposure of
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