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Biodegradable poly(α-amino acids) can serve as chemical carriers of active agents. The narcotic antagonist naltrexone and the anti-hypertensive minox idil were covalently coupled to polymer backbones based upon L-glutamic acid to give polymeric prodrugs. The synthesis and release characteristics...
Some vinyl polymers by fixing 5FUs via carbamoyl bonds on organosilicon groups were synthesized by means of ordinary radical polymerization of the corresponding monomers. These hybrid type vinyl polymers with 5FU and or ganosilicon amine units exhibited significant antitumor activities against...
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