1 - 10 of 11 articles
Targeted polymeric prodrugs based on N-(2-hydroxypropyl) methacrylamide were tested on human peripheral blood lymphocytes or mouse splenocytes triggered in vitro to proliferation by T cell specific (Con A) or B cell specific (S. aureus Cowan 1) mitogens. Only a selective inhibition of 3H-...
Water soluble non-stoichiometric polyelectrolyte complexes have been investigated as potential drug carrier systems for parenteral administra tion. Complexes between the polycationic quaternized poly(vinyl imidazole) (QPVI) and an excess of a higher molecular weight partially sulfonated dextran...
Two copolymers of maleic anhydride, 10-undecendyl chloride-co- maleic anhydride and acryloyl chloride-co-maleic anhydride, were synthesized, esterified with chloramphenicol, and tested for antimicrobial activity via Kirby-Bauer disk sensitivity and broth dilution methods. Both polymer-drug...
Chemical modification of chitin led to a series of derivatives: chi tosan, N-acetylchitosan, monoacetylchitin, dibutyrylchitin, chitosan acetate, chitosan butyrate, chitosan citrate and chitosan-poly(acrylic acid) complex. These were used to coat glass surfaces and studied with respect to their...
An overview of the subject of biodegradable microcapsular drug delivery systems is presented from a polymer chemist's viewpoint. Various polymerization and microencapsulation techniques (including emulsion polymerization, interfacial polycondensation, suspension crosslinking, coacer vation/phase...
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