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In order to compare the fates of end-chain-radiolabelled and repeat-unit-radiolabelled poly(β-malic acid)s after intravenous injection in mice, repeat-unit 14C-radiolabelling of this biodegradable water-soluble poly carboxylic acid polymer was achieved starting from 14C-aspartic acid. The ac...
N-Carboxybutyl chitosan obtained from crustacean chitin was used to assist the spontaneous tissue repair of the meniscus, which is usually of extreme difficulty. Results indicate that this natural modified polysaccharide is well-tolerated at the articular synovial level. It also favors and...
The dissolution kinetics, in an aqueous medium, of a water solu ble drug dispersed in an insoluble polymeric matrix, depends highly on the drug loading. A computer model of cisplatin loaded poly(lactide-co-glycolide) microspheres dissolution confirms the hypothesis that only the drug crystals...
The synthesis, characterization, and reactivity of alternating copolymers of maleic anhydride (MA) with new vinyl ethers of mono-O-methyl oligoethylene glycol (MePegnVE, degree of oligomerization n = 1-4) are described. The linear MA/PegnVE copolymers were partially esterified with alcohols such...
This study examines the biocompatibility of two different syn thetic copolymers; a water soluble copolymer based on [N-(2-hydroxypropyl) methacrylamide] (HPMA) and an insoluble polymer based on 2-hydroxyethyl methacrylate (HEMA). Activation of classical and alternative complement pathways,...
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