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Tb monitor the fate of alginate following systemic administration, a method was developed that allowed the covalent incorporation of approximately 1 mol% tyrosinamide. The product could be radioiodinated to a high specific activity, and was subsequently stable on storage at 4°C for 30 days, with...
Effects of the osmotic pressure of culture medium on the membrane fusion of L929 cells in the monolayer state were investigated using polyethylene glycol) (PEG) with the molecular weight of 3,000 at various concentrations at phosphate buffer saline (PBS). Cell incubation for fusion was performed...
The preparation of new hydrogels by the reaction of α,β- polyasparthydrazide and glutaraldehyde is reported. A different crosslinking degree was obtained by varying the ratio crosslinking agent/polymer which influenced the swelling behavior of the gel. 5-Fluorouracil, was incorporated into the...
The interaction of α-chymotrypsin covalently bound to quaternized poly(4-vinylpyridine) with oppositely charged latex particles was investigated and compared with that of free a-chymotrypsin. The free enzyme and the corresponding polymer conjugates were added to a mixture of two latexes: one...
Doxorubicin (adriamycin; ADR) which is one of the most clinically used antitumor agent, has undesirable side-effects. To reduce these side-effects, a macromolecular prodrug of ADR exhibiting high antitumor activity, the conjugate of PEG end-capped with ADR was developed. Tb effect intracellular...
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