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N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer-adriamycin (ADR) conjugate (P-aconityl-ADR) was synthesized by the attachment of cis-aconityl-ADR to an HPMA copolymer precursor using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as the condensing agent. The ADR release from the HPMA...
Poly(ethylene glycol) (PEG) and Pluronic® F-127 (PF127) were silylated with 3-isocyanatopropyltriethoxysilane to synthesize PEG-based hydrogels by sol-gel transition of silane. Silanes on different PEG molecules formed covalent bonds by acid-catalyzed hydrolysis and condensation. Addition of...
One of the key technologies for regeneration of damaged and lost tissue is the sustained release of biologically active growth factors. The present study was undertaken to investigate sorption and desorption of various growth factors from biodegradable hydrogels prepared through glutaraldehyde...
Poly(methylmethacrylate-co-2-hydroxyethylmethacrylate) microbeads in the size range of 1.5-2.0μm were prepared by a phase inversion polymerization. The hydroxyl groups were activated by periodate oxidation, and the active ligand, i.e., protein A was immobilized via a spacer-arm, i.e.,...
Segmented poly(tartaramide)s were prepared by polycondensation of monodispersed α,ω-diaminooligo(ethyleneglycol)s, with oligomerization degree included between 2 and 6, with two optically active dialkyl tartrates. The diamines were obtained from the relevant commercial glycols using a modified...
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