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The synthesis and the physicochemical evaluation of a series of polyethylene oxide (PEO) containing polyamines are described as potential vectors in gene therapy. Two different types of vectors were synthesized: PEO block copolymers and copolymers containing PEO grafts. The building unit of the...
Novel ribozymes containing 2'-amino groups in the side chains were in vitro selected to accelerate their ligation reaction rates with oligodeoxynucleotides. The ligation rate of random sequenced RNAs in the starting pool was accelerated by incorporation of 2'-amino-2'-deoxyuridine and...
Human vascular endothelial growth factors (VEGF) are angiogenic factors that induce specific endothelial cell proliferation. In this study, VEGF165, which contains 165 amino acids, was immobilized onto poly(acrylic acid) grafted polyethylene) films (PAAc-g-PE). VEGF165 was immobilized via a...
The effect of Fe3+ chelates of polyethers having terminal 8-quinolinol (8Q) residues linked to the polymer chain at different ring positions on the remedy of iron-deficient maize plants was studied. It was found that Fe3+ chelates of polymers with 8Q groups attached at the 5-position (HOQ-P-QOH)...
Using a set of natural coiled-coil proteins as models, a series of recombinant proteins were designed and expressed in E. coli. These proteins contain a consensus coiled-coil sequence as a framework into which were incorporated positively or negatively charged residues at selected positions. A...
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