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Biodegradable hybrid hydrogels from chemically modified dextran and poly(DL)lactic acid (PDLLA) were prepared by UV photocrosslinking of different molecular weights (MWs) of these precursors. A series biodegradable hybrid hydrogels were obtained by changing the composition ratio of hydrogels and...
The partitioning of ganglioside (GM3,GD1a, GD1b or GT1b)-reconstituted liposomes was investigated in an aqueous poly(ethylene oxide)/dextran two-phase system to evaluate the carbohydrate–carbohydrate interactions in water. The partitioning of the ganglioside-reconstituted liposome was strongly...
The synthesis of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers and semi-telechelic polymers (PHPMA) conjugates superoxide dismutase (SOD) is described. The polymer was conjugated with SOD by means ofnondegradable or degradable oligopeptide spacers randomly distributed along the polymer...
Poly(ethylene glycol) (PEG)-substituted macromolecular mitomycin C (MMC)-derivatives were synthetized using poly[N5-(2-hydroxyethyl)-L-glutamine] as the polymeric backbone. As an oligopeptide spacer between the drug and the polymer, tetrapeptide gly-phe-ala-leu was selected. To study the...
Tumor-selective macromolecular ligands containing 5-(p-Carbonyloxyphenyl)-10,15,20-triphenylporphyrin (HPTP) moiety (PHEA-DTPAHPTP and PAEA-DTPA-HPTP) were prepared by the incorporation of diethylenetriaminepentaacetic acid (DTPA) and 5-(p-hydroxylphenyl)-10,15, 20-triphenylporphyrin (HPTP) as...
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