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This is the first demonstration of receptor-mediated delivery of mRNA and establishes a new approach to gene therapy. Messenger RNA (mRNA) provides a promising alternative to plasmid DNA as a genetic material for delivery in non-viral gene therapy strategies. Since it does not require access to...
A copolymer of N-isopropyl acrylamide (NIPAAm) and acrylic acid (AAc), Mw 1,400, AAc content of 3.1 mmol carboxylic acid groups per gram of the copolymer, was synthesised by a free radical polymerisation. Mono-, di-, and tripeptide conjugates of this copolymer were prepared by using the...
Conjugates ofanionic polyelectrolytes (PE) with betulin (PE–B) were synthesized by cross-linking the carboxyl groups oftemperature responsive poly(N-isopropylacrylamide-co-acrylic acid) (CP1) and poly(N-vinylpyrrolidoneco-acrylic acid) (CP2) copolymers, to the hydroxyl groups ofbetulin using...
The adsorption and covalent coupling of bovine serum albumin (BSA) onto methylmethacrylate (MMA) based monodisperse latex particles with different hydrophylic surfaces were investigated. P(MMA) and P(MMA/HEMA) microbeads in the size range of 1.5–2.0 mm were prepared by a dispersion...
Block copolymers have a potential utility as drug carriers. In order to study their in vivo fate, the biodegradable block copolymer poly(D,L- lactide ethylene oxide) (PLA/PEO) (Mw 5000/5000) with a p-methoxyphenyl moiety was radio labeled with 125I. The copolymer was [125I] iodinated in the...
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