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A precise control over the internal architecture was essential for manufacture of complex organs. To create vascular systems that mimic human livers, we designed and fabricated complex 3D objects with an intrinsic network of interconnected channels....
Biodegradable nanoparticles, as drug delivery paradigms, have been extensively used for delivery of a wide range of small molecules as well as macromolecules, such as peptides, proteins, and genes. The morphological modification may improve the...
This study involved a statistical approach to develop a mechanistic understanding of the salting-out of poly(lactic-co-glycolic acid) (PLGA) and to evaluate the capacity to modulate the physicochemical and physicomechanical properties of PLGA by incorporating electrolytes that produce stochastic...
A new route for the synthesis of novel amphiphilic polysaccharides was developed, in which a synthetic biodegradable poly(ε-caprolactone) was capped with a phenylalanine group (PCL-phenylalanine). The ring-opening polymerization of ε-caprolactone (ε-CL) was carried out in the absence of a metal...
Hydrogel microspheres were prepared from the major softwood hemicellulose polysaccharide acetylated galactoglucomannan. The dry and swollen morphology was assessed by scanning electron microscopy. The microspheres were loaded with either a small hydrophilic substance (caffeine) or a...
The determination of drug permeability is an important part of formulation, development, and studying the effect of excipients on drug delivery processes. Ketotifen, FITC-labeled dextran, and Rhodamine 123 permeation was evaluated across Caco-2 cells grown on permeable inserts in the presence of...
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