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Recently discovered mutations in 2 genes, BRCA1 and BRCA2, account for most hereditary cases of breast cancer. Individuals with mutations in either BRCA1 or BRCA2 carry an elevated lifetime risk of breast or ovarian cancer. Genetic testing for these mutations now allows individuals to learn if...
The p53 gene plays a critical role in the regulation of cell growth. Mutations of this gene are associated with transformation to a malignant phenotype. Correcting the gene defect through transfer of a wild-type p53 gene into malignant cells and targeting malignant cells with oncolytic viruses...
Skin cancer is the most prevalent carcinoma in the USA. To preventrejection, transplant patients are subjected to intense immunosuppression that cancauseseemingly banalskin lesions to become aggressive and life threatening. Patient and physician education is necessary to inform those who are...
Magnetic resonance imaging is ideally suited for visualizing the cardiovascular system by providing images with high spatial and temporal resolution. These images are acquired in the absence of ionizing radiation, in any tomographic plane, and without interference from surrounding bone or soft...
Tremendous advances have been made in orthopaedic surgery since its inception over 250 years ago. Although subspecialties such as spinal surgery, orthopaedic oncology, and hand surgery have made significant technological and biological advances in the past 40 years, 3 broad areas have...
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