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The sulphated polymers, such as polyvinylalcohol sulphate (PVAS) and its co-polymer with acrylic acid (PAVAS), have proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, vesicular stomatitis virus, respiratory syncytial virus, Sindbis virus, Semliki Forest virus, Junin...
The substituted pyrimidinone immunomodulators 5-bromo-2,3-dihydro-2-imino-6-phenyl-4(1H)-pyrimidinone (ABPP), 5-iodo-2,3-dihydro-2-imino-6-phenyl-4(1H)-pyrimidinone (AIPP), 5-bromo-2,3-dihydro-2-imino-6-methyl-4(1H)-pyrimidinone (ABMP), 5-chloro-2,3-dihydro-2-imino-6-phenyl-4(1H)-pyrimidinone...
The thymidine analogue 3′-azido-3′-deoxythymidine (AZT), whilst a useful drug for the treatment of acquired immunodeficiency syndrome, produces toxic side-effects which can be severe and can interfere with therapy. The toxic mechanism of AZT is unknown. We have investigated the relationship...
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