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Poly(1-methyl-6-thioinosinic acid), or PMTI, is a single-stranded polyribonucleotide and is the first homopolyribonucleotide devoid of Watson—Crick hydrogen bonding sites to show potent human immunodeficiency virus (HIV) inhibition. PMTI was found to be active when evaluated against a variety of...
A series of chemically oversulphated galactosaminoglycans (SO3H:COOH ratio ≥2) were tested in vitro as antiviral agents against human immunodeficiency virus type 1 (HIV-1), the aetio-logical agent of AIDS, and against herpes simplex virus type 1 and human cytomegalovirus, two agents responsible...
The potency and selectivity index of the AZT-phenyl phosphate derivatives in thymidine kinase (TK)-deficient T cells were substantially enhanced by introducing a single para-bromo substituent in the phenyl moiety. AZT-5′-(p-bromophenyl methoxyalaninyl phosphate) was 43-fold more potent than...
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