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Two series of new nucleoside derivatives, acyclic nucleosides and tricyclic base nucleosides, were screened for cellular toxicity and against HIV-1. Compounds were tested on MT4, MT2, U937 cell lines and PBMCs in multiwell tissue culture plates. Cells were infected in vitro with 2 TCID50/105...
2′,3′-dideoxyinosine (ddl) and 2′,3′-dideoxythymidiene (d4T) have been reported to inhibit the multiplication of human immunodeficiency virus (HIV) in patients, ddl and d4T were administered subcutaneously to cynomolgus monkeys starting 8 h prior to inoculation with 10–50 infectious doses of...
A novel assay system has been developed in which expression of a human tissue-plasminogen activator (t-PA) gene, carried on a recombinant papillomavirus vector, is used as a marker for the presence of bovine papillomavirus type 1 (BPV-1) within transformed mouse C127 cells. This provides a...
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