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The anionic compounds, aurintricarboxylic acid, Evans blue, glycyrrhizic acid, taurolithocholic acid, and fuchsin acid, have been tested for their capacity to inhibit the replication of African swine fever virus (ASFV) in Vero cells. Aurintricarboxylic acid suppressed ASFV cytopathic effects at...
5-methoxymethyl-N4-methyl-2′-deoxycytidine (N4-Me-MMdCyd) and 5-methoxymethyl-N4-methyl-2′-deoxycytidine-5′-monophosphate (N4-Me-MMdCMP) were synthesized to confer resistance to deamination by deaminating enzymes. N4-Me-MMdCyd and N4-Me-MMdCMP were inactive against Herpes simplex virus type 1...
Peptides, corresponding to amino acid sequences in the cytoplasmic domains of the transmembranal glycoproteins encoded by Sindbis and vesicular stomatitis viruses, inhibited release of virus particles and infectious virus when added to infected cells for a 2h period during a one-cycle growth...
Mice inoculated intranasally with a potentially lethal dose of HSV-1 (strain SC16) were used to evaluate the efficacy of penciclovir (PCV) and its oral form, famciclovir (FCV) in the treatment of acute herpes encephalitis. In a comparative experiment, orally administered PCV was less effective...
Several compounds developed for use as dyes have shown activity against HIV-1. The present study examines one putative mechanism of this anti-HIV activity, inhibition of gp120/CD4 binding, and its contribution to the antiviral effects of three chemical classes of dyes. Although, for most dyes,...
Recent observations that haernin inhibited the replication of the human immunodeficiency virus (HIV-1) and the reaction between the HIV-1 envelope glycoprotein gp120 and antibodies specific for the V3 hypervariable loop of this glycoprotein were an enticement to determine whether or not...
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