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Journal of the American Society for Mass Spectrometry

Subject Areas: Structural Biology
Publisher: American Chemical Society - American Chemical Society
ISSN: 1879-1123
SJR: 130

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Journal Article

Differentiating Toxic and Nontoxic Tricresyl Phosphate Isomers Using Ion–Molecule Reactions with Oxygen

Amiri, Roshanak; Bissram, Meera J.; Hashemihedeshi, Mahin; Dorman, Frank L.; Megson, David; Jobst, Karl J.

2023 Journal of the American Society for Mass Spectrometry

doi:10.1021/jasms.2c00334 pmid:36942790

Ortho-substituted isomers of tricresyl phosphates (TCPs) and their toxic metabolites (e.g., CBDP: cresyl saligenin phosphate) can cause neurotoxic effects in humans. When TCP is introduced to an atmospheric pressure chemical ionization source using gas chromatography, radical cations M•+ are...
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Journal Article

Collision Induced Dissociation of Deprotonated Isoxazole and 3‑Methyl Isoxazole via Direct Chemical Dynamics Simulations

Priya, Himani; Paranjothy, Manikandan

2023 Journal of the American Society for Mass Spectrometry

doi:10.1021/jasms.2c00366 pmid:36951239

Isoxazoles are an important class of organic compounds widely employed in synthesis and drug design. Fragmentation chemistry of the parent isoxazole molecule and its substituents has been the subject of several experimental and theoretical investigations. Collision induced dissociation (CID) of...
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Journal Article

Investigation of 2‑Hydroxypropyl-β-Cyclodextrin Treatment in a Neuronal-Like Cell Model of Niemann–Pick Type C Using Quantitative Proteomics

Cougnoux, Antony; Pergande, Melissa R.; Serna-Perez, Fidel; Cologna, Stephanie M.

2023 Journal of the American Society for Mass Spectrometry

doi:10.1021/jasms.2c00342 pmid:36920149

Niemann–Pick, type C (NPC) is a fatal, neurovisceral lysosomal storage disorder with progressive neurodegeneration and no FDA-approved therapy. Significant efforts have been focused on the development of therapeutic options, and 2-hydroxypropyl-β-cyclodextrin (HP-b-CD) has emerged as a promising...
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Journal Article

Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer’s Disease

Quinn, James P.; Ethier, Elizabeth C.; Novielli, Angelo; Malone, Aygul; Ramirez, Christopher E.; Salloum, Lauren; Trombetta, Bianca A.; Kivisäkk, Pia; Bremang, Michael; Selzer, Stefan; Fournier, Marjorie; Das, Sudeshna; Xing, Yaoyi; Arnold, Steven E.; Carlyle, Becky C.

2023 Journal of the American Society for Mass Spectrometry

doi:10.1021/jasms.2c00341

The granin neuropeptide family is composed of acidic secretory signaling molecules that act throughout the nervous system to help modulate synaptic signaling and neural activity. Granin neuropeptides have been shown to be dysregulated in different forms of dementia, including Alzheimer’s disease...
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Journal Article

Effects of Long-Term Storage on the Biobanked Neonatal Dried Blood Spot Metabolome

Ottosson, Filip; Russo, Francesco; Abrahamsson, Anna; MacSween, Nadia; Courraud, Julie; Nielsen, Zaki Krag; Hougaard, David M.; Cohen, Arieh S.; Ernst, Madeleine

2023 Journal of the American Society for Mass Spectrometry

doi:10.1021/jasms.2c00358 pmid:36913955

Over 2.5 million neonatal dried blood spots (DBS) are stored at the Danish National Biobank. These samples offer extraordinary possibilities for metabolomics research, including prediction of disease and understanding of underlying molecular mechanisms of disease development. Nevertheless,...
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Journal Article

Exploring Isomerism in Isolated Cyclodextrin Oligomers through Trapped Ion Mobility Mass Spectrometry

Chakraborty, Papri; Neumaier, Marco; Weis, Patrick; Kappes, Manfred M.

2023 Journal of the American Society for Mass Spectrometry

doi:10.1021/jasms.2c00351 pmid:36952473

Cyclodextrin (CD) macrocycles are used to create a wide range of supramolecular architectures which are also of interest in applications such as selective gas adsorption, drug delivery, and catalysis. However, predicting their assemblies and identifying the possible isomers in CD oligomers have...
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Journal Article

Faces of Mass Spectrometry/Evgenia Shishkova

Brenner, Anne; Meierdiercks, Laurel

2023 Journal of the American Society for Mass Spectrometry

doi:10.1021/jasms.3c00086 pmid:36947861
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Journal Article

Multistage Ion Mobility Spectrometry Combined with Infrared Spectroscopy for Glycan Analysis

Bansal, Priyanka; Ben Faleh, Ahmed; Warnke, Stephan; Rizzo, Thomas R.

2023 Journal of the American Society for Mass Spectrometry

doi:10.1021/jasms.2c00361 pmid:36881006

The structural complexity of glycans makes their characterization challenging, not only because of the presence of various isomeric forms of the precursor molecule but also because the fragments can themselves be isomeric. We have recently developed an IMS-CID-IMS approach using structures for...
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Journal Article

Fate of Gold Nanoparticles in Laser Desorption/Ionization Mass Spectrometry: Toward the Imaging of Individual Nanoparticles

Prysiazhnyi, Vadym; Bednařík, Antonín; Žalud, Michal; Hegrová, Veronika; Neuman, Jan; Preisler, Jan

2023 Journal of the American Society for Mass Spectrometry

doi:10.1021/jasms.2c00300 pmid:36917818

This study focuses on mapping the spatial distribution of Au nanoparticles (NPs) by laser desorption/ionization mass spectrometry imaging (LDI MSI). Laser interaction with NPs and associated phenomena, such as change of shape, melting, migration, and release of Au ions, are explored at the...
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Journal Article

Global Discovery and Temporal Changes of Human Albumin Modifications by Pan-Protein Adductomics: Initial Application to Air Pollution Exposure

Smith, Joshua W.; O’Meally, Robert N.; Burke, Sean M.; Ng, Derek K.; Chen, Jian-Guo; Kensler, Thomas W.; Groopman, John D.; Cole, Robert N.

2023 Journal of the American Society for Mass Spectrometry

doi:10.1021/jasms.2c00314 pmid:36939690

Assessing personal exposure to environmental toxicants is a critical challenge for predicting disease risk. Previously, using human serum albumin (HSA)-based biomonitoring, we reported dosimetric relationships between adducts at HSA Cys34 and ambient air pollutant levels (Smith et al., Chem....

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