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We are using selective breeding to develop lines of mice which differ maximally in their response to nicotine, and independent lines of mice which differ maximally in their responses to cocaine. The foundation population was the genetically heterogeneous HS mice. On day 1, baseline (saline...
One line (strain) of mouse has been selectively bred in our laboratory for 15 generations to exhibit a very high sensitivity to levorphanol-induced analgesia on the hot plate assay (HAR or high antinociceptive response line). Concurrently, a second line (LAR or low antinociceptive response line)...
Benzoniazepine (BZ) effects include anxiolyis, sedation, seizure protection, and muscle relaxation; the mechanisms underlying these variouis effects are not understood. We have recently used the rotarod test in conjunction with selective breeding techniques to develop lines of mice which are...
One recent advance in the field of alcohol research has been the recognition that a predisposition to develop alcoholism is, in part, genetically determined. It now remains to identigy the approach to this problem is to analyze how organisms with identifiable genetic predisposition towards...
The use of Recombinant Inbred mouse Strains (RIS) to derive information about the complexity of the genetic architecture underlying various traits is increasing in popularity. Behaviors measured to index sensitivity to drug effects and vulnerability to drug abuse are considered here. Potential...
Long-sleep (LS) and short-sleep (SS) mice which were selectivity bred for sensitivity to the sedative-hypnotic effects of ethanol have been used extensively in the examination of sensitivity to ethanol as well as to other CNS depressants. Understanding the relationship between sensitivity to...
Human twin studies have indicated that genetic factors influence whether people do, or do not, smoke and may also influence amount of tobacco used. Studies in the authors' laboratory have demonstrated that inbred mouse strains differ in sensitivity to many actions of a fist challenge dose of...
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