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D‐Ser(tBu)‐L‐Phe‐L‐Trp is described as a self‐assembling tripeptide that yields nanofibrillar hydrogels at physiological conditions (phosphate buffer at pH 7.4). The peptide is characterized by several spectroscopic methods, such as circular dichroism and fluorescence, oscillatory rheometry, and...
The synthesis of Gobichelin‐A, a naturally occurring mixed‐ligand siderophore isolated from Streptomyces sp. NRRL F‐4415, is described. The target molecule was planned to be synthesized by a convergent process involving the combination of two halves, Gob‐A 1st half and Gob‐A 2nd half, at the...
Antibiotic‐resistant bacterial infections are becoming a serious health issue and will cause 10 million deaths per year by 2050. As a result, the development of new antimicrobial agents is urgently needed. Antimicrobial peptides (AMPs) are found in the innate immune systems of various organisms...
Elucidation of protein function is one of the central issues in the field of life sciences. To study the function of proteins not in isolation, but in a cell or its lysate, thus, it is necessary to selectively label the target protein in a mixture. Affinity labeling is one of several widely used...
Obestatin is a gastrointestinal system peptide. The quantification of this peptide is conventionally performed using immunological techniques. In this study, a selective and sensitive HPLC method coupled with fluorescence detection for the quantitation of obestatin in human plasma was developed...
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