Journal of Mammary Gland Biology and Neoplasia

Journal Article

Valine Treatment Enhances Antimicrobial Component Production in Mammary Epithelial Cells and the Milk of Lactating Goats Without Influencing the Tight Junction Barrier

Tsugami, Yusaku; Nii, Takahiro; Isobe, Naoki

2023 Journal of Mammary Gland Biology and Neoplasia

doi:10.1007/s10911-023-09529-x pmid:36801983

The production of antimicrobial components and the formation of less-permeable tight junctions (TJs) are important in the defense system of lactating mammary glands and for safe dairy production. Valine is a branched-chain amino acid that is actively consumed in the mammary glands and promotes...

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Journal Article

Culture Models to Investigate Mechanisms of Milk Production and Blood-Milk Barrier in Mammary Epithelial Cells: a Review and a Protocol

Kobayashi, Ken

2023 Journal of Mammary Gland Biology and Neoplasia

doi:10.1007/s10911-023-09536-y pmid:37126158

Mammary epithelial cells (MECs) are the only cell type that produces milk during lactation. MECs also form less-permeable tight junctions (TJs) to prevent the leakage of milk and blood components through the paracellular pathway (blood-milk barrier). Multiple factors that include hormones,...

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Journal Article

Longitudinal analysis of bovine mammary gland development

Vang, Alysia L.; Bresolin, Tiago; Frizzarini, Waneska S.; Menezes, Guilherme L.; Cunha, Thiago;

2023 Journal of Mammary Gland Biology and Neoplasia

doi:10.1007/s10911-023-09534-0 pmid:37249685

Many studies on bovine mammary glands focus on one stage of development. Often missing in those studies are repeated measures of development from the same animals. As milk production is directly affected by amount of parenchymal tissue within the udder, understanding mammary gland growth along...

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Journal Article

Molecular Characterization and Landscape of Breast cancer Models from a multi-omics Perspective

Ortiz, Mylena M.O.; Andrechek, Eran R.

2023 Journal of Mammary Gland Biology and Neoplasia

doi:10.1007/s10911-023-09540-2 pmid:37269418

Breast cancer is well-known to be a highly heterogenous disease. This facet of cancer makes finding a research model that mirrors the disparate intrinsic features challenging. With advances in multi-omics technologies, establishing parallels between the various models and human tumors is...

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Journal Article

FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation

Mieczkowski, Kamil; Popeda, Marta; Lesniak, Dagmara; Sadej, Rafal; Kitowska, Kamila

2023 Journal of Mammary Gland Biology and Neoplasia

doi:10.1007/s10911-023-09537-x pmid:37191822

The role of fibroblast growth factor receptor 2 (FGFR2), an important mediator of stromal paracrine and autocrine signals, in mammary gland morphogenesis and breast cancer has been extensively studied over the last years. However, the function of FGFR2 signalling in the initiation of mammary...

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Journal Article

ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author

Morato, Alessia; Accornero, Paolo; Hovey, Russell C.

2023 Journal of Mammary Gland Biology and Neoplasia

doi:10.1007/s10911-023-09538-w pmid:37219601

The ERBB tyrosine kinase receptors and their ligands belong to a complex family that has diverse biological effects and expression profiles in the developing mammary glands, where its members play an essential role in translating hormone signals into local effects. While our understanding of...

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Journal Article

Characterization of Hyaluronan Localization in the Developing Mammary Gland and Mammary Tumors

Witschen, Patrice M.; Elfstrum, Alexis K.; Nelson, Andrew C.; Schwertfeger, Kathryn L.

2023 Journal of Mammary Gland Biology and Neoplasia

doi:10.1007/s10911-023-09528-y pmid:36723776

The extracellular matrix (ECM) is biochemically and biomechanically important for the structure and function of the mammary gland, which undergoes vast structural changes throughout pubertal and reproductive development. Although hyaluronan (HA) is a ubiquitous glycosaminoglycan (GAG) of the...

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Journal Article

The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad

Fricke, Hannah P; Hernandez, Laura L

2023 Journal of Mammary Gland Biology and Neoplasia

doi:10.1007/s10911-023-09535-z pmid:37086330

Lactation is a physiological adaptation of the class Mammalia and is a product of over 200 million years of evolution. During lactation, the mammary gland orchestrates bone metabolism via serotonin signaling in order to provide sufficient calcium for the offspring in milk. The role of serotonin...

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Journal Article

Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential

Cordero, Alex; Santamaría, Patricia G.; González-Suárez, Eva

2023 Journal of Mammary Gland Biology and Neoplasia

doi:10.1007/s10911-023-09530-4 pmid:36808257

Determination of the mammary epithelial cell that serves as the cell of origin for breast cancer is key to understand tumor heterogeneity and clinical management. In this study, we aimed to decipher whether Rank expression in the presence of PyMT and Neu oncogenes might affect the cell of origin...

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Journal of Mammary Gland Biology and Neoplasia

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