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Controlled clinical trials performed in more than 13 000 patients have, to date, consistently shown the beneficial effects of long term β-adrenoceptor antagonist (β-blocker) therapy in patients with chronic heart failure. It is not clear whether this represents a class effect or whether it is...
Atherosclerosis and intimal hyperplasia remain obstacles for surgeons to overcome following vascular reconstructions. Even with all of the technical improvements that have occurred in the past several decades, long term patency following intervention is hindered by these inherent adverse...
This article reviews the fundamentals of myocardial energy metabolism and selectively outlines the use of several metabolically active drug therapies in the treatment of ischemic heart disease. These drugs — ranolazine, trimetazidine, dichloroacetate (DCA), glucose-insulin-potassium (GIK)...
Chronic heart failure (CHF) in children occurs mostly as a result of systolic dysfunction of the systemic ventricle or of congenital defects leading to large left-to-right shunts and pulmonary overcirculation. The ensuing symptoms and signs are similar in both cases, and include respiratory...
Venous thromboembolism is a common and potentially fatal disease. If properly used, anticoagulation therapy is effective in preventing recurrence of venous thromboembolism and in improving survival. Symptomatic patients with an objective diagnosis of acute deep vein thrombosis (DVT) or pulmonary...
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