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In clinical trials in patients with acute or unstable coronary syndromes and/or undergoing percutaneous coronary intervention, oral glycoprotein (GP) IIb/IIIa antagonists did not show therapeutic benefit over aspirin during long-term administration. Moreover, high-dose oral administration of...
The new European Guidelines in Hypertension: Critical Analysis
The new American Guidelines: Critical Analysis
Over the past decade, a large number of studies have demonstrated that tumor necrosis factor-alpha (TNFα) plays an important role in the development of heart failure. Indeed, administration of TNFα to experimental animals and transgenic over-expression of TNFα replicate the heart failure...
The latest European Guidelines for the treatment of hypertension recommend the use of low-dose combination therapies as the first line strategy.
Improving the systolic and pulse pressure components of blood pressure, arterial stiffness and left ventricular hypertrophy in hypertensive patients treated with the perindopril/indapamide combination. The REASON Study.
Cardiac transplantation is the definitive treatment for eligible patients with end-stage cardiac failure. Techniques have evolved to reduce surgical mortality to under 5%. Immediate and subsequent long-term survival is more dependent on acute and chronic rejection and the complications of...
Coronary microvascular remodeling and ischemia in hypertension
Microalbuminuria is a strong marker for progressive renal damage and an increased risk of mortality, especially from cardiovascular disease, in patients with type 1 or type 2 diabetes and hypertension. The benefits of blood pressure reduction in patients with diabetes and hypertension are well...
Eptifibatide, a molecule isolated from the venom of the southeastern pygmy rattlesnake, selectively inhibits the platelet receptor IIb/IIIa. The safety and clinical efficacy of eptifibatide in patients undergoing percutaneous coronary intervention (PCI) was first evaluated in the Integrilin to...
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