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Abstract Methods that had been applied to study central neuronal circuits regulating cough and respiratory reflexes so far rely on recording performed in vivo, ex vivo, micro injecting and lesion methods. Based on the available data it is clear that this network is complicated, multilevel,...
Abstract Cough is the most common symptom of many respiratory diseases. Currently, no standardized methods exist for objective monitoring of cough, which could be commercially available and clinically acceptable. Our aim is to develop an algorithm which will be capable, according to the sound...
Abstract Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Cough is a major symptom in some people with asthma. Cough reflex sensitivity (CRS) test with capsaicin is one of the most important method for cough studying. Cough reflex...
Abstract Histamine is one of the most important biogenic amines and it mediates numbers of physiological processes. It is also involved in majority of inflammatory diseases via its receptors H 1 , H 2 , H 3 and H 4 . The role of histamine had been recognized as substantial in many allergic...
Abstract Visceral pain brings deep medical burden to society, and it is clinically often the first symptom which leads to a medical consultation. In the time of deeper understanding of molecular transducers in pain pathways, there is still need for models to test hypothesis how would selective...
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