Endocrine Related Cancer

Journal Article

Metabolomics in paraganglioma: applications and perspectives from genetics to therapy

Richter, Susan; Garrett, Timothy J; Bechmann, Nicole; Clifton-Bligh, Roderick J; Ghayee, Hans K

2023 Endocrine Related Cancer

doi:10.1530/erc-22-0376 pmid:36897220

Metabolites represent the highest layer of biological information. Their diverse chemical nature enables networks of chemical reactions that are critical for maintaining life by providing energy and building blocks. Quantification by targeted and untargeted analytical methods using either mass...

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Journal Article

Reactivated thyroid hormone receptor β attenuates anaplastic thyroid cancer (ATC) stem cell activity

Zhu, Xuguang; Zhao, Li; Doolittle, Woo Kyung Lee; Cheng, Sheue-yann

2023 Endocrine Related Cancer

doi:10.1530/erc-22-0306 pmid:36939877

Anaplastic thyroid cancer (ATC) is one of the most aggressive solid cancers in humans, with limited treatment options. Recent studies suggest that cancer stem cell (CSC) activity contributes to therapeutic resistance and recurrence of ATC. We show that the expression of the endogenous thyroid...

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Journal Article

Interventional vs surgical procedures in localized/nonmetastatic insulinomas (ablation vs surgery)

Sada, Alaa; McKenzie, Travis J; Vella, Adrian; Levy, Michael J; Halfdanarson, Thorvardur R

2023 Endocrine Related Cancer

doi:10.1530/erc-22-0362 pmid:36952635

Localized insulinoma is an uncommon entity that can result in substantial morbidity due to the associated hypoglycemia. Recent studies have suggested an increase in the incidence of insulinoma in recent decades that may possibly be secondary to increased awareness, incidental diagnoses, and...

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Journal Article

Cancer in Ecuadorian subjects with Laron syndrome (ELS)

Guevara-Aguirre, Jaime; Peña, Gabriela; Pazmiño, Gabriel; Acosta, William; Saavedra, Jannette;

2023 Endocrine Related Cancer

doi:10.1530/erc-22-0389 pmid:36971780

Meta-analyses from 2018–2022 have shown that obesity increases the risk of various cancers such as acute myeloid lymphoma, chronic myeloid lymphoma, diffuse beta cell lymphoma, Hodgkin's lymphoma, leukemia, multiple myeloma, non-Hodgkin's lymphoma, bladder, breast, cholangiocarcinoma, colorectal,...

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Journal Article

Talking about sex: erectile dysfunction in the oncology patient

Romeo, Marilina; Spaggiari, Giorgia; Furini, Chiara; Granata, Antonio R M; Toss, Angela;

2023 Endocrine Related Cancer

doi:10.1530/erc-22-0401 pmid:36971778

Cancer-related diagnosis and treatments can profoundly affect every aspect of an individual’s life. The negative impact on the sexual sphere can manifest with onset or worsening of the most frequent male form of sexual dysfunction, that is the erectile dysfunction (ED), with an estimated...

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Journal Article

Germline pathogenic variants in patients with early-onset neuroendocrine neoplasms

Riechelmann, Rachel Pimenta; Donadio, Mauro Daniel Spina; de Jesus, Victor Hugo Fonseca; de Angelis de Carvalho, Nathalia; Santiago, Karina Miranda;

2023 Endocrine Related Cancer

doi:10.1530/erc-22-0258 pmid:36947458

Neuroendocrine neoplasms (NENs) are a rare group of cancers with heterogeneous behaviour and mostly of unknown aetiology. Excluding some infrequent hereditary cancer syndromes, the extent and clinical significance of mutations in other cancer predisposing genes (CPGs) are not known. We aimed to...

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Journal Article

Diffuse sclerosing variant papillary thyroid carcinoma has worse survival than classic papillary thyroid carcinoma: a meta-analysis

Crayton, Henry; Wu, Katherine; Leong, David; Bhimani, Nazim; Gild, Matti;

2023 Endocrine Related Cancer

doi:10.1530/erc-22-0348 pmid:36952650

Diffuse sclerosing variant (DSV) of papillary thyroid carcinomais a rare form of thyroid cancer that demonstrates more aggressive histopathology than classical papillary thyroid carcinoma (c-PTC); however, if this leads to worse survival is debated. Many DSVs are driven by fusion events which are...

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Journal Article

COVID-19 in patients with neuroendocrine neoplasms: 2-year results of the INTENSIVE study

Fazio, Nicola; Gervaso, Lorenzo; Halfdanarson, Thorvardur R; Sonbol, Mohamad; Eiring, Rachel A;

2023 Endocrine Related Cancer

doi:10.1530/erc-22-0395

We conducted a retrospective/prospective worldwide study on patients with neuroendocrine neoplasms (NENs) and a molecularly proven SARS-CoV-2 positivity. Preliminary results regarding 85 patients of the INTENSIVE study have been published in 2021. Now we are reporting the 2-year analysis.Here, we...

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Journal Article

Proteomic analysis of small intestinal neuroendocrine tumors and mesenteric fibrosis

Blažević, Anela; Iyer, Anand M; van Velthuysen, Marie-Louise F; Hofland, Johannes; Franssen, Gaston J H;

2023 Endocrine Related Cancer

doi:10.1530/erc-22-0237 pmid:36951556

Mesenteric metastases in small intestinal neuroendocrine tumors (SI-NETs) are associated with mesenteric fibrosis (MF) in a proportion of patients. MF can induce severe abdominal complications, and an effective preventive treatment is lacking. To elucidate possible novel therapeutic targets, we...

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