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Objective To evaluate the antiretroviral activity and safety of multiple escalating doses of amprenavir administered alone, and in combination with abacavir in HIV-1-infected adults. Design Sixty-two HIV-1-infected subjects were enrolled in a multicentre, open-label, non-randomized,...
Objectives To investigate adherence to antiretroviral therapy over 48 weeks, to investigate the association between adherence and treatment-related symptoms and to investigate the impact of adherence on virological response over 48 weeks among established predictors of treatment success. Methods...
Objective To assess antiretroviral efficacy and safety of abacavir in combination with selected HIV-1 protease inhibitors. Design A 48-week, open-label study. Materials and Methods Eighty-two antiretroviral naive HIV-1-infected adults (CD4 cell count ≥100 cells/mm3, plasma HIV-1 RNA ≥5000...
The presence of the HIV reverse transcriptase (RT) resistance mutation, M184V, induced by lamivudine and abacavir treatment results in increased tenofovir, adefovir and zidovudine susceptibility for HIV-1 with zidovudine-associated RT mutations in vitro. Treatment with oral prodrugs of tenofovir...
The objective of our randomized, multicentre, double-blind, placebo-controlled study was to investigate the safety, tolerability, and antiretroviral and immunological effect of double and triple combination therapy regimens. A total of 105 antiretroviral therapy-naive patients were randomized to...
Objectives To demonstrate that lamivudine and zidovudine, given separately (lamivudine/zidovudine) or as a single combination tablet (Combivir™), had equivalent efficacy. To evaluate the safety and antiretroviral activity of intensification with abacavir in patients treated with...
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