Molecular Cancer Research

Journal Article

2022 Molecular Cancer Research

Mutant NRASG12V drives acute myeloid leukemia (AML) cell proliferation and self-renewal in a mutually exclusive manner. Previous studies demonstrated that AML cell proliferation and self-renewal are associated with differential NRASG12V transcript levels, but whether different NRASG12V protein...

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The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Anderson, Kenneth C.; Cantley, Lewis C.; Dalla-Favera, Riccardo; Dang, Chi Van; Diaz, Luis A.;

2022 Molecular Cancer Research

doi:10.1158/1541-7786.mcr-22-0804 pmid:36325685

The American Association for Cancer Research (AACR) is the first and largest cancer research organization dedicated to accelerating the conquest of cancer. The stated purpose of the organization when it was founded 115 years ago was “to further the investigation and spread the knowledge of...

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A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog–Dependent Tumor Growth

Yang, Fan; Rodriguez-Blanco, Jezabel; Long, Jun; Swiderska-Syn, Marzena; Wynn, Daniel T.;

2022 Molecular Cancer Research

doi:10.1158/1541-7786.mcr-22-0182 pmid:35925047

Dysregulation of Sonic hedgehog (SHH) signaling drives the growth of distinct cancer subtypes, including medulloblastoma (MB). Such cancers have been treated in the clinic with a number of clinically relevant SHH inhibitors, the majority of which target the upstream SHH regulator, Smoothened...

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CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of SUSD2

Wu, Yanjie; Duan, Yang; Li, Xuanyuan; Zhao, Ran; Lan, Bei;

2022 Molecular Cancer Research

doi:10.1158/1541-7786.mcr-22-0139 pmid:35894945

Polycomb group proteins are often dysregulated in cancer, leading to disruption of epigenetic landscapes and acquisition of cancer hallmarks. Chromobox 8 (CBX8) is a core component of canonical polycomb repressive complex 1; however, its role in transcriptional regulation and in ovarian carcinoma...

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Functional Characterization of lncRNA152 as an Angiogenesis-Inhibiting Tumor Suppressor in Triple-Negative Breast Cancers

Kim, Dae-Seok; Camacho, Cristel V.; Setlem, Rohit; Kim, Kangsan; Malladi, Srinivas;

2022 Molecular Cancer Research

doi:10.1158/1541-7786.mcr-22-0123 pmid:35997635

Long noncoding RNAs have been implicated in many of the hallmarks of cancer. Herein, we found that the expression of lncRNA152 (lnc152; a.k.a. DRAIC), which we annotated previously, is highly upregulated in luminal breast cancer (LBC) and downregulated in triple-negative breast cancer (TNBC)....

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LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3

Qiu, Xin; Shi, Qiuyue; Zhang, Xianglian; Shi, Xiaoyan; Jiang, Haixing;

2022 Molecular Cancer Research

doi:10.1158/1541-7786.mcr-22-0024 pmid:35920801

Ferroptosis is a newly-discovered cell death mechanism involved in the progression of various tumors, the role of noncoding RNAs (ncRNAs) in it was relatively less explored. This study identified the low levels of a recently studied long noncoding RNA (lncRNA), A2M-AS1, in pancreatic cancer and...

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Proliferation and Self-Renewal Are Differentially Sensitive to NRASG12V Oncogene Levels in an Acute Myeloid Leukemia Cell Line

Kurata, Morito; Antony, Marie Lue; Noble-Orcutt, Klara E.; Rathe, Susan K.; Lee, Yoonkyu;

2022 Molecular Cancer Research

doi:10.1158/1541-7786.mcr-22-0109 pmid:35900472

NRAS proteins are central regulators of proliferation, survival, and self-renewal in leukemia. Previous work demonstrated that the effects of oncogenic NRAS in mediating proliferation and self-renewal are mutually exclusive within leukemia subpopulations and that levels of oncogenic NRAS vary...

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Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia

Roma, Alessia; Tcheng, Matthew; Ahmed, Nawaz; Walker, Sarah; Jayanth, Preethi;

2022 Molecular Cancer Research

doi:10.1158/1541-7786.mcr-21-1032 pmid:35994381

Acute myeloid leukemia (AML) is a hematologic malignancy metabolically dependent on oxidative phosphorylation and mitochondrial electron transport chain (ETC) activity. AML cells are distinct from their normal hematopoietic counterparts by this metabolic reprogramming, which presents targets for...

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DNA Methyltransferase 3B–Mediated Intratumoral Heterogeneity and Therapeutic Targeting in Breast Cancer Recurrence and Metastasis

So, Jae Young; Yang, Howard H.; Park, Woo Yong; Skrypek, Nicolas; Ishii, Hiroki;

2022 Molecular Cancer Research

doi:10.1158/1541-7786.mcr-21-0887 pmid:35857355

The mechanisms of how cancer cells are selected and evolve to establish distant metastatic colonies remain unclear. Tumor heterogeneity and lack of biomarkers are some of the most difficult challenges in cancer biology and treatment. Here using mouse models for triple-negative breast cancer...

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Circ_0001821 Affects Proliferation and the Cell Cycle in Esophageal Squamous Cell Carcinoma by Elevating BTRC-Mediated IKBA Ubiquitination

Lin, Changjin; Wei, Yujun; Duan, Xinchun; Liu, Chunquan; Du, Yanlin;

2022 Molecular Cancer Research

doi:10.1158/1541-7786.mcr-22-0023 pmid:35913453

Esophageal squamous cell carcinoma (ESCC) is a fatal human cancer featured with a tendency to metastasis and relapse. Increasing studies have emphasized the critical roles of circular RNAs (circRNA) in ESCC. This study targeted at a novel circRNA and uncovering its function and mechanisms in...

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Molecular Cancer Research

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