1 - 10 of 42 articles
We must stop conceptualizing and presenting donors as either “good” and “bad”: simplistic dual variables ignore the reality of the donor pool.
The combination of severe depletion with alemtuzumab followed by later immunosuppressive drug weaning raises many concerns that need to be assessed in an objective, controlled, IRB‐approved approach. See also article by Tan et al in this issue on page 2409.
The evaluation and implementation of new protocols for transplanting highly‐sensitized patients should be a high priority to reduce the morbidity and mortality faced by these people on the transplant waiting list. See also article by Bray et al in this issue on page 2307.
Hepatitis C virus (HCV) infection is a major health care issue in liver and kidney transplantation. Besides negatively affecting both patient and graft survival, HCV is associated with a heightened risk for new onset diabetes mellitus (NODM). The mechanisms underlying the diabetogenicity of HCV...
The first successful human hand transplantation, performed on September 1998, has translated the scope of ‘composite tissue allotransplantation’ from research concepts into clinical practice. Beyond microsurgical problems that have been overcome several years ago, the main obstacle that still...
Carbon monoxide (CO), a byproduct of heme catalysis, was shown to have potent cytoprotective and anti‐inflammatory effects. In vivo recipient CO inhalation at low concentrations prevented ischemia/reperfusion (I/R) injury associated with small intestinal transplantation (SITx). This study...
Renal tubular epithelial cells (TEC) die by apoptosis or necrosis in renal ischemia‐reperfusion injury (IRI). Fas/Fas ligand‐dependent fratricide is critical in TEC apoptosis, and Fas promotes renal IRI. Therefore, targeting Fas or caspase‐8 may have therapeutic potential for renal injury in...
The goal of this study was to determine the in vivo conditions that promote activation of the (CD4‐independent) CD8+ T cell‐mediated rejection pathway. We have previously noted that hepatocellular but not islet allografts readily activate this rejection pathway. In the current study, we utilized...
In many experimental models, heart, pancreas and kidney allografts are accepted long‐term following costimulation‐targeting therapies, whereas skin, lung and intestine resist the induction of tolerance under the same regimens. We noted that a common feature of the resistant organs is their...
Chronic allograft nephropathy (CAN) is a leading cause of kidney graft failure following transplantation. Its causes are complex and include both immunological and nonimmunological factors. Here we have studied the development of CAN in a mouse model of kidney transplantation comparing isografts...
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