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Influenza viruses are important infections in transplant recipients. They may lead to complications including viral pneumonia, secondary bacterial infections and graft dysfunction. There has been a recent widespread outbreak of highly pathogenic H5N1 avian influenza among domestic poultry and...
Recent experiences with combinations of calcineurin inhibitor plus sirolimus compared to calcineurin inhibitor plus mycophenolate remind us that claims based on early anecdotal experiences with immunosuppressive protocols must be greeted with caution until controlled trials are available. See...
Regardless of our discomfort about hidden costs, and our reluctance to consider uncomfortable moral choices, “more of the same” is increasingly unacceptable as a solution to the present crisis in the availability of organ transplants for those in need. See also article by Rothman et al in this...
As experience with donation after cardiac death in controlled situations grows, the potential for donation after cardiac death in the less controlled situations should now be carefully examined, and the challenges of utilizing such organs and the ethical and logistical challenges associated with...
The development of an animal model of polyoma virus nephropathy is an important objective, but many questions still remain before current models can be accepted as reflecting the conditions of clinical polyoma virus nephropathy. See also article by Larsen et al AJT 6(5):913‐922.
The critical issue for the future of desensitization is not the comparison between methods but the development of better tools to assess the extent of sensitization and use the tools optimally to address the problems of the individual.
Migration behavior of regulatory T cells critically influences their suppressive activities in vivo and expression of chemokine receptors, selectins, and integrins.
The idea of establishing a market for organs is now the subject of unusual controversy. Proponents emphasize the concept of autonomy; opponents invoke fairness and justice. The controversy, however, has given sparse attention to what it would mean to society and medicine to establish a market in...
Polyethylene glycol (PEG), a high‐molecular weight colloid, is added to preservation solutions in order to decrease cold‐ and ischemia‐induced injuries of the grafted organ. We evaluated on LLC‐PK1, a porcine proximal tubular epithelial cell line (1) the efficiency of several commercial...
Exosomes are MHC‐bearing vesicles secreted by a wide array of cells. We have previously shown that donor‐haplotype exosomes from bone marrow dendritic cells (DCs) injected before transplantation significantly prolong heart allograft survival in congenic and fully MHC‐mismatched Lewis rats. Here...
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