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Considering the limited long‐term survival of islet transplants, the degree of renal damage observed in islet transplants is a concern. See also article by Senior et al in this issue on page 91.
Recent work by several groups defines the important role of the Toll‐like receptors in alloimmunity.
Recently, Galα1‐3Galβ1‐4GlcNAc (Gal) knockout (k/o) pigs have been developed using genetic cloning technologies. This remarkable achievement has generated great enthusiasm in xenotransplantation studies. This review summarizes the current status of nonhuman primate experiments using Gal k/o pig...
Tribute to the late Dr. Robert Zhen Zhong by two of his former colleagues. Also in this issue please see several articles by this author, including a minireview on page 5, and two original articles on pages 17 and 27.
The author argues that “The Institute of Medicine Report, Organ Donation: Opportunities for Action” missed opportunities to try to increased the number of organ donors; the net effect is to maintain the status quo.
Renal NOS2 is expressed and produces abundant nitric oxide (NO) in various renal cells in response to proinflammatory cytokines. However, the role of this enzyme in renal allograft survival remains unknown. Kidney allotransplantation was performed in the murine model of C57BL/6J (H‐2d) to...
Previously, an anti‐CD45RB monoclonal antibody (mAb) has been shown to induce murine allograft tolerance. The present study was performed to assess the ability of an anti‐human CD45RB mAb to prevent rejection in a monkey MHC‐mismatched kidney transplant model. The recipients were allocated into...
We have developed a luminol‐based assay using intact islets, which allows for quantification of reactive oxygen species (ROS). In addition, an index capable of characterizing metabolic and mitochondrial integrity prior to transplantation was created based on the capacity of islets to respond to...
Ischemia and reperfusion injury remains a relevant problem in clinical pancreas transplantation. We investigated the effect of sirolimus (SRL) in a rodent model of 90‐min warm pancreatic ischemia. Four groups were studied: (1) sham surgery and vehicle; (2) sham surgery and SRL; (3) warm ischemia...
Murine heterotopic cardiac allografts were used to reveal some of the fundamental interrelationships between donor‐specific alloantibodies (DSA), chronic transplant arteriopathy (CTA) and capillary C4d deposition. B10.BR recipients of B10.A hearts developed transient DSA and C4d deposition that...
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