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A new study challenges the CMS decision to lower a center's annual number of acceptable heart transplants, but does lower volume really mean increased mortality?
While salvage liver transplantation for patients with recurrent HCC after liver resection is feasible in the current organ shortage, what is less certain is whether this strategy will provide our patients with the best available treatment. Please see article by Del Gaudio et al in this issue on...
Current approaches to screening of donors are inadequate to prevent donor‐derived infections, and both new procedures and new technology should be implemented, but emphasizing cost effectiveness and avoiding exclusions due to false positive tests.
Medical tourism has emerged as a global health care phenomenon, valued at $60 billion worldwide in 2006. Transplant tourism, unlike other more benign forms of medical tourism, has become a flashpoint within the transplant community, underscoring the uneasy relationships among science, religion,...
The enthusiasm regarding clinical islet transplantation has been dampened by the long‐term results. Concerns about the associated risks of life‐long immunosuppression and the striking imbalance between potential recipients and available donor pancreata warrant changes in some of the current...
Incompatibility between pig thrombomodulin (TM) and primate thrombin is thought to be an important factor in the development of microvascular thrombosis in rejecting pig‐to‐primate xenografts. To examine this interaction at the molecular level, we cloned pig TM and measured its ability to bind...
Despite success of early islet allograft engraftment and survival in humans, late islet allograft loss has emerged as an important clinical problem. CD8+ T cells that are independent of CD4+ T cell help can damage allograft tissues and are resistant to conventional immunosuppressive therapies....
We explored whether a functionally blocking anti‐C5 monoclonal antibody (mAb) combined with T‐ and B‐cell immunosuppression can successfully prevent antibody‐mediated (AMR) and cell‐mediated rejection (CMR) in presensitized murine recipients of life‐supporting kidney allografts. To mimic the...
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