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This month, “The AJT Report” reviews the problems clinicians, scientists and industry face in tackling acute antibody‐mediated rejection in transplant patients, and provides an update on the U.K. transplant system since it moved to a national organ donation and procurement system two years ago.
The new Editor‐in‐Chief presents opening thoughts.
The author gives a contemporary assessment on the scoring and clinical significance of glomerulitis in renal allograft biopsies with reference to the accompanying article by Batal et al on page 2442.
The authors examine trends in donation after cardiac death (DCD) and donation after brain death (DBD) to assess whether expansion of the donor pool by augmenting DCD has occurred to the detriment of DBD. See brief communication by Saidi et al on page 2536.
Jean Hamburger, one of the pioneers of scientific medicine in the mid‐20th century, who was involved in the inception of intensive care, nephrology, hemodialysis and scientific clinical research, has also been one of the very few fathers of human organ transplantation. He was involved in the...
In murine models, mixed hematopoietic chimerism induction leads to robust immune tolerance. However, translation to primates and to patients has been difficult. In this study, we used a novel MHC‐defined rhesus macaque model to examine the impact of MHC matching on the stability of costimulation...
We have shown that CD39 and CD73 are coexpressed on the surface of murine CD4+Foxp3+ regulatory T cells (Treg) and generate extracellular adenosine, contributing to Treg immunosuppressive activity. We now describe that CD39, independently of CD73, is expressed by a subset of blood‐derived human...
Ischemia/reperfusion injury and delayed graft function (DGF) following organ transplantation adversely affect graft function and survival. A large animal model has not been characterized. We developed a pig kidney allograft model of DGF and evaluated the cytoprotective effects of inhaled carbon...
As we have shown in the past, acute rejection‐related TNF‐α upregulation in resident macrophages in the tunica muscularis after small bowel transplantation (SBTx) results in local amplification of inflammation, decisively contributing to graft dysmotility. Therefore, the aim of this study is to...
Transplant glomerulitis is an increasingly recognized lesion in renal transplant biopsies. To develop a refined grading system, we defined glomerulitis by the presence of ≥5 leukocytes/glomerulus and evaluated 111 biopsies using three different grading systems: (i) percentage of glomerular...
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