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Regulatory T cells (Treg) are currently being tested in clinical trials as a potential therapy in cell and solid organ transplantation. The immunosuppressive drug rapamycin has been shown to preferentially promote Treg expansion. Here, we hypothesized that adjunctive rapamycin therapy might...
An artificial pancreas that would automatically monitor and respond to blood glucose would be life altering for insulin‐dependent diabetics. While past safety concerns have stalled FDA approval for clinical trials, development now appears to be progressing again. Also this month, a look at the...
Several new reports further the understanding of the role of commensal microbes in reducing and shaping the T cell receptor repertoire of intestinal induced regulatory T cells, which in turn prevent inflammation at environmental interfaces, providing knowledge that may relate to the optimal care...
Increasing the use of kidneys recovered from diabetic deceased donors is an important alternative with potential to reduce the growing disparity between patients on the wait list and the number of organs available for transplantation. See article by Mohan et al on page 2098.
The author opines that the Kidney Donor Risk Index better predicts the outcomes and utilization of deceased donor kidneys when compared to the currently used standard and expanded criteria donor labels. See article by Woodside et al on page 2106.
This editorial highlights the need for stakeholders to clarify acceptable trade‐offs as a prerequisite to assessment of different deceased donor kidney allograft algorithms, such as that proposed by Ross et al. See page 2115.
Cardiovascular disease is the leading cause of mortality in kidney transplant recipients. Dyslipidemia is a common finding after renal transplantation and a significant risk factor in the development of coronary heart disease. Although a causal relationship with cardiovascular mortality has not...
On December 1, 2011, in Flynn v. Holder, a panel of the US Court of Appeals for the Ninth Circuit upheld the National Organ Transplant Act of 1984 (NOTA) from a constitutional challenge, but interpreted the act such that its prohibition on sale did not encompass “peripheral blood stem cells”...
Public reports of organ transplant program outcomes by the US Scientific Registry of Transplant Recipients have been both groundbreaking and controversial. The reports are used by regulatory agencies, private insurance providers, transplant centers and patients. Failure to adequately adjust...
We hypothesized that Nox2, the classical phagocytic NADPH oxidase, plays an important role in calcineurin inhibitor (CNI)‐induced renal fibrosis. We tested this hypothesis in vitro, in animal and in human studies. Cyclosporine A (CsA) and tacrolimus (TAC) were associated with greater levels of...
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