1 - 10 of 38 articles
This month, we look at a variety of ways transplant centers are coping with the increased volume and complexity of organ offers. Also this month, we look at six OPTN/UNOS proposals open for public comment.
Several studies offer a better understanding of skin immunology that should improve understanding of the complex immune mechanisms leading to VCA rejection or acceptance.
Programmed cell necrosis is a newly recognized entity with interplay in the innate immune response and ischemia‐reperfusion injury, and it may play an important role in allograft rejection. See minireview by Linkermann et al on page 2797 and article by Lau et al on page 2805.
Intragraft antibody detection opens new avenues for research and clinical decision‐making. See article by Bachelet et al on page 2855.
This editorial examines the potential relationship between allograft health and cognitive function in long‐term survivors of pediatric liver transplantation. See article by Kaller et al on page 2956.
The authors discuss plasma cell–rich hepatitis in liver transplant recipients and further implications regarding its etiopathogenesis, diagnosis, treatment and relevance for organ dysfunction. See article by Castillo‐Rama et al on page 2966.
This editorial reviews the implications and impact of the UNOS policy of prioritization of patients with hepatocellular carcinoma for liver transplantation. See brief communication by Schuetz et al on page 2989.
Transplantation is invariably associated with ischemia–reperfusion injury (IRI), inflammation and rejection. Resultant cell death has morphological features of necrosis but programmed cell death has been synonymous with apoptosis until pathways of regulated necrosis (RN) have been described. The...
Kidney transplant injury occurs with ischemia and alloimmunity. Members of the receptor interacting protein kinase family (RIPK1,3) are key regulators of “necroptosis,” a newly recognized, regulated form of necrosis. Necroptosis and apoptosis death appear to be counterbalanced as caspase‐8...
Foxp3+ regulatory T cells (Tregs) have an essential role in immune and allograft tolerance. However, in both kidney and liver transplantation in humans, FOXP3+ Tregs have been associated with clinical rejection. Therefore, the role and function of graft infiltrating Tregs have been of great...
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