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This spring, a district court judge ordered that two children receive increased priority for lungs from adolescent and adult donors. We explore what this ruling might mean for the future of OPTN policy. Also in this issue, we look at a new Health and Human Services guideline designed to minimize...
Several recent reports hypothesize a link between the microbiota within transplanted organs and the alloreactive responses elicited. This month, we review new evidence for infl ammasome activation mediating this link.
While the field has focused largely on Foxp3+ Tregs as mediators of regulatory allograft tolerance, a new study provides evidence that a ‘division of labor’ can occur between Tregs and IL‐10‐producing Tr1 cells in which each regulatory cell type can be required during differing phases of the...
The evaluation of transplant center performance requires innovative solutions to improve accuracy and promote the best interests of patients. See article by Massie and Segev on page 2044.
The authors discuss the implications of a novel approach to deceased donor liver distribution that designs new OPTN regions by combining low and high organ availability donation service areas. See article by Gentry et al on page 2052.
Solid phase HLA antibody detection assays are quite good, and though imperfect, they convey valuable information. See article by Gombos et al on page 2075.
The intent of the PHS guideline is to improve organ transplant recipient outcomes by reducing the risk of unexpected HIV, HBV and HCV transmission, while preserving the availability of high‐quality organs. An evidence‐based approach was used to identify the most relevant studies and reports on...
The immune system is comprised of several CD4+ T regulatory (Treg) cell types, of which two, the Foxp3+ Treg and T regulatory type 1 (Tr1) cells, have frequently been associated with transplant tolerance. However, whether and how these two Treg‐cell types synergize to promote allograft tolerance...
A strategy for inhibiting CD40 has been considered as an alternative approach for immunosuppression because of undesirable effects of anti‐CD154 monoclonal antibodies (mAbs). Previously, we demonstrated that ASKP1240, which is a fully human anti‐CD40 mAb, significantly prolonged kidney and liver...
We examined the influence of regulatory dendritic cells (DCreg), generated from cytokine‐mobilized donor blood monocytes in vitamin D3 and IL‐10, on renal allograft survival in a clinically relevant rhesus macaque model. DCreg expressed low MHC class II and costimulatory molecules, but...
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