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A new study points to an overall decline in living donor volume in the United States. “The AJT Report” takes a look at possible reasons for the downturn. Also in this issue, we discuss two back‐to‐work programs for transplant recipients.
Several studies highlight the crucial role of Foxo transcription factors in regulatory T cell function, aiding in the development of therapeutic strategies using these cells to modulate alloimmune responses.
This editorial puts into perspective the significance of a decade‐old sirolimus trial in relation to the current status of mTOR inhibitors in liver transplantation. See article by Asrani et al on page 356.
The authors opine on why the complication rates reported in Uchiyama et al (page 367) are not congruent with the existing literature.
This editorial addresses the indication for combined heart–kidney transplantation, challenging Schaffer et al's (page 384) recommendations of giving higher priority status exemptions to patients listed for multiple organs.
Advances in multimodal immunotherapy have significantly reduced acute rejection rates and substantially improved 1‐year graft survival following renal transplantation. However, long‐term (10‐year) survival rates have stagnated over the past decade. Recent studies indicate that antibody‐mediated...
The 12th Banff Conference on Allograft Pathology was held in Comandatuba, Brazil, from August 19–23, 2013, and was preceded by a 2‐day Latin American Symposium on Transplant Immunobiology and Immunopathology. The meeting was highlighted by the presentation of the findings of several working...
We utilized mouse models to elucidate the immunologic mechanisms of functional graft loss during mixed antibody‐mediated rejection of renal allografts (mixed AMR), in which humoral and cellular responses to the graft occur concomitantly. Although the majority of T cells in the graft at the time...
While it is well known that CD4+ T cells and B cells collaborate for antibody production, our group previously reported that CD8+ T cells down‐regulate alloantibody responses following transplantation. However, the exact mechanism involved in CD8+ T cell–mediated down‐regulation of alloantibody...
Allostimulation with concurrent costimulatory blockade induces alloantigen‐specific hyporesponsiveness in responder T cells (“alloanergization”). Alloanergized responder cells also acquire alloantigen‐specific suppressive activity, suggesting this strategy induces active immune tolerance. While...
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