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On the cover this month: Although much attention is appropriately focused on the immunobiology of allotransplantation and its relationship to the immune management of transplant recipients, it is important to reflect on the critical importance of superb surgical technique in determining...
This month, we speak with Sir Roy Calne and Terry Strom, both honored as “innovators in transplantation” at the 2015 American Transplant Congress, about their careers and the future of transplantation.
New studies identify critical pathways involved in the generation of CD4+ TFH cells.
The authors argue for greater attention to donor complications and suitable training for organ donor surgeons to improve outcomes in organ transplantation. See also articles from Heylen et al on page 2900 and Ausania et al on page 2955.
Longitudinal assessment of a B cell tolerance signature among operationally tolerant and control cohorts of kidney transplant recipients, along with extension into new cohorts of treated subjects, uncovers additional surprises and questions. See article from Newell et al on page 2908.
Innate lymphoid cells (ILC) are lymphocytes lacking rearranged antigen receptors such as those expressed by T and B cells. ILC are important effector and regulatory cells of the innate immune system, controlling lymphoid organogenesis, tissue inflammation, and homeostasis. The family of ILC...
Research reports presented at the American Transplant Congress 2015 provided an array of basic science findings of relevance to the transplant community. Among key themes is the concept that ischemia–reperfusion injury and early posttransplantation inflammation is linked to adaptive alloimmunity...
Innovative and exciting advances in the clinical sciences in organ transplantation were presented at the American Transplant Congress 2015. The full spectrum of transplantation was covered, with important developments in many topics. Key areas covered by presentations included living donor...
Epstein–Barr virus (EBV) is a γ‐herpesvirus that is linked to the development of posttransplant lymphoproliferative disorder (PTLD) in solid organ recipients. We previously demonstrated that EBV+ B cell lymphoma cell lines isolated from patients with PTLD produce human IL‐10 as an autocrine...
CD40–CD154 pathway blockade prolongs renal allograft survival in nonhuman primates (NHPs). However, antibodies targeting CD154 were associated with an increased incidence of thromboembolic complications. Antibodies targeting CD40 prolong renal allograft survival in NHPs without thromboembolic...
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