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In 1963, Lepow and colleagues resolved C1, the first component of the classical pathway, into three components, which they named C1q, C1r, and C1s. All three of these components were demonstrated to be involved in causing hemolysis in vitro. For over 30 years after that seminal discovery, the...
Mesenchymal stem cells (MSC) have been shown to be immunomodulatory, tissue regenerative, and graft promoting; however, several questions remain with regard to ideal MSC source and timing of administration. In this study, we utilized a rigorous preclinical model of allogeneic islet cell...
IL‐12 (p35/p40) and IL‐23 (p19/p40) signal through IL‐12R (IL‐12Rβ2/β1) and IL‐23R (IL‐23Rα/IL‐12Rβ1), respectively, which can promote pathogenic T lymphocyte activation, differentiation, and function in graft‐versus‐host disease (GVHD). With the use of murine models of allogeneic hematopoietic...
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