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Marine Drugs

Subject Areas: Drug Discovery
Publisher: Multidisciplinary Digital Publishing Institute - Multidisciplinary Digital Publishing Institute
ISSN: 1660-3397
SJR: 128

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Journal Article

Molecular Cloning and Characteristics of a Lectin from the Bivalve Glycymeris yessoensis

Mizgina, Tatyana O.; Baldaev, Sergey N.; Likhatskaya, Galina N.; Molchanova, Valentina I.; Kokoulin, Maxim S.; Filshtein, Alina P.; Rogozhin, Eugene A.; Chikalovets, Irina V.; Isaeva, Marina P.; Chernikov, Oleg V.

2023 Marine Drugs

doi:10.3390/md21020055 pmid:36827096

C-type lectins (CTLs) are a family of carbohydrate-binding proteins that mediate multiple biological events, including adhesion between cells, the turnover of serum glycoproteins, and innate immune system reactions to prospective invaders. Here, we describe the cDNA cloning of lectin from the...
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Journal Article

A Survey of Didemnin Depsipeptide Production in Tistrella

Stankey, Robert J.; Johnson, Don; Duggan, Brendan M.; Mead, David A.; La Clair, James J.

2023 Marine Drugs

doi:10.3390/md21020056 pmid:36827097

As one of the first families of marine natural products to undergo clinical trials, the didemnin depsipeptides have played a significant role in inspiring the discovery of marine drugs. Originally developed as anticancer therapeutics, the recent re-evaluation of these compounds including...
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Journal Article

In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications

Martins, Eva; Reis, Rui L.; Silva, Tiago H.

2023 Marine Drugs

doi:10.3390/md21020057 pmid:36827098

The industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish...
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Journal Article

Molecular Networking Revealed Unique UV-Absorbing Phospholipids: Favilipids from the Marine Sponge Clathria faviformis

Scarpato, Silvia; Teta, Roberta; De Cicco, Paola; Borrelli, Francesca; Pawlik, Joseph R.; Costantino, Valeria; Mangoni, Alfonso

2023 Marine Drugs

doi:10.3390/md21020058 pmid:36827099

Analysis of extracts of the marine sponge Clathria faviformis by high-resolution LC-MS2 and molecular networking resulted in the discovery of a new family of potentially UV-protecting phospholipids, the favilipids. One of them, favilipid A (1), was isolated and its structure determined by mass...
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Journal Article

Characterization of the Biophysical Properties and Cell Adhesion Interactions of Marine Invertebrate Collagen from Rhizostoma pulmo

Smith, Ian P.; Domingos, Marco; Richardson, Stephen M.; Bella, Jordi

2023 Marine Drugs

doi:10.3390/md21020059 pmid:36827101

Collagen is the most ubiquitous biomacromolecule found in the animal kingdom and is commonly used as a biomaterial in regenerative medicine therapies and biomedical research. The collagens used in these applications are typically derived from mammalian sources which poses sociological issues due...
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Journal Article

Large-Scale Cultivation of Magnetotactic Bacteria and the Optimism for Sustainable and Cheap Approaches in Nanotechnology

de Souza Cabral, Anderson; Verdan, Mariana; Presciliano, Rogerio; Silveira, Felipe; Correa, Tarcisio; Abreu, Fernanda

2023 Marine Drugs

doi:10.3390/md21020060 pmid:36827100

Magnetotactic bacteria (MTB), a diverse group of marine and freshwater microorganisms, have attracted the scientific community’s attention since their discovery. These bacteria biomineralize ferrimagnetic nanocrystals, the magnetosomes, or biological magnetic nanoparticles (BMNs), in a...
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Journal Article

Characterization of the Native Disulfide Isomers of the Novel χ-Conotoxin PnID: Implications for Further Increasing Conotoxin Diversity

Espiritu, Michael J.; Taylor, Jonathan K.; Sugai, Christopher K.; Thapa, Parashar; Loening, Nikolaus M.; Gusman, Emma; Baoanan, Zenaida G.; Baumann, Michael H.; Bingham, Jon-Paul

2023 Marine Drugs

doi:10.3390/md21020061 pmid:36827103

χ-Conotoxins are known for their ability to selectively inhibit norepinephrine transporters, an ability that makes them potential leads for treating various neurological disorders, including neuropathic pain. PnID, a peptide isolated from the venom of Conus pennaceus, shares high sequence...
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Journal Article

Green Synthesis of TiO2 Nanoparticles Using Natural Marine Extracts for Antifouling Activity

Alarif, Walied M.; Shaban, Yasser A.; Orif, Mohammed I.; Ghandourah, Mohamed A.; Turki, Adnan J.; Alorfi, Hajer S.; Tadros, Hermine R. Z.

2023 Marine Drugs

doi:10.3390/md21020062 pmid:36827102

Titanium dioxide (TiO2) nanoparticles were synthesized via a novel eco-friendly green chemistry approach using marine natural extracts of two red algae (Bostrychia tenella and Laurencia obtusa), a green alga (Halimeda tuna), and a brown alga (Sargassum filipendula) along with a marine sponge...
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Journal Article

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

Wang, Jiamin; Qin, Yuning; Lin, Miaoping; Song, Yingying; Lu, Humu; Xu, Xinya; Liu, Yonghong; Zhou, Xuefeng; Gao, Chenghai; Luo, Xiaowei

2023 Marine Drugs

doi:10.3390/md21020063 pmid:36827104

Marine natural products (MNPs) play an important role in the discovery and development of new drugs. The Beibu Gulf of South China Sea harbors four representative marine ecosystems, including coral reefs, mangroves, seaweed beds, and coastal wetlands, which are rich in underexplored marine...
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Journal Article

Dinophysis acuminata or Dinophysis acuta: What Makes the Difference in Highly Stratified Fjords?

Baldrich, Ángela M.; Díaz, Patricio A.; Álvarez, Gonzalo; Pérez-Santos, Iván; Schwerter, Camila; Díaz, Manuel; Araya, Michael; Nieves, María Gabriela; Rodríguez-Villegas, Camilo; Barrera, Facundo; Fernández-Pena, Concepción; Arenas-Uribe, Sara; Navarro, Pilar; Reguera, Beatriz

2023 Marine Drugs

doi:10.3390/md21020064 pmid:36827105

Dinophysis acuminata and D. acuta, which follows it seasonally, are the main producers of lipophilic toxins in temperate coastal waters, including Southern Chile. Strains of the two species differ in their toxin profiles and impacts on shellfish resources. D. acuta is considered the major cause...

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