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Researchers have recently demonstrated a significant activity in the use of antiangiogenic compounds for the treatment of clear-cell metastatic renal cell carcinoma (RCC). The pVHL protein plays an important role in angiogenesis. Germline or somatic alterations of the VHL gene result in an...
Renal cell carcinoma (RCC) is the sixth leading cause of cancer-related deaths and is responsible for an estimated 95,000 deaths worldwide. Metastatic RCC is refractory to radiation therapy and traditional chemotherapy. Treatment of metastatic RCC with either interleukin 2 (IL-2) or...
Tumor growth and survival requires both proliferative and angiogenic signals, involving many molecular pathways. There is increasing preclinical and clinical evidence that agents targeting more than one pathway or receptor may be more efficacious in inducing tumor regression and disrupting tumor...
The epidermal growth factor receptor (EGFR) autocrine pathway plays a crucial role in human cancer, contributing to a number of highly relevant processes in tumor development and progression, including cell proliferation, regulation of apoptotic cell death, angiogenesis, and metastatic spread....
The World Health Organization (WHO) has classified T-cell malignancies into mature T-cell and natural killer (NK)-cell neoplasms and precursor T-cell lymphoblastic lymphoma/leukemia. Mature T-cell lymphomas, alternatively known as peripheral T-cell lymphomas (PTCLs), are rare diseases with...
The presence of lymph node metastasis is predictive of poor prognosis in solid tumors. Demonstration of specific markers of lymphatic endothelial cells has facilitated the study of the molecular mechanisms of metastasis, particularly lymphangiogenesis. The vascular endothelial growth factor...
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