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Oncology Letters Volume 7 Issue 4

Subject Areas: Cancer Research
Publisher: Spandidos Publications - Spandidos Publications
ISSN: 1792-1074
SJR: 63

LitStream

Journal Article

A furin inhibitor downregulates osteosarcoma cell migration by downregulating the expression levels of MT1‑MMP via the Wnt signaling pathway

Liu, Bingshan; Li, Guojun; Wang, Xiao; Liu, Yang

2014 Oncology Letters

doi:10.3892/ol.2014.1839 pmid:24944664

This study aimed to explore the exact mechanism of the effect of a furin inhibitor on the migration and invasion of MG‑63 and Saos‑2 osteosarcoma cells. MG‑63 and Saos‑2 osteosarcoma cells were treated with regular culture medium in the presence or absence of 480 nM α1‑antitrypsin Portland...
LitStream

Journal Article

Successful pregnancy following conservative management of low‑grade endometrial stromal sarcoma: A case report

Dong, Ruiying; Pang, Yingxin; Mao, Hongluan; Yang, Ning; Liu, Peishu

2014 Oncology Letters

doi:10.3892/ol.2014.1858 pmid:24944665

It is uncommon that fertility is preserved in young nulliparous females with low‑grade endometrial stromal sarcoma (ESS). Therefore, successful pregnancy following such conservative management has been rarely reported in previous literature. A 25‑year‑old female (gravida, 0; para, 0) underwent...
LitStream

Journal Article

Role of microRNA‑133a in epithelial ovarian cancer pathogenesis and progression

Luo, Jie; Zhou, Jianhong; Cheng, Qi; Zhou, Caiyun; Ding, Zhiming

2014 Oncology Letters

doi:10.3892/ol.2014.1841 pmid:24944666

It has been demonstrated that microRNA (miR)‑133a is downregulated in a number of human malignancies and is closely associated with the progression of tumors. The present study was conducted to investigate the contribution of miR‑133a to the initiation and malignant progression of human...
LitStream

Journal Article

Pancreatic body adenocarcinoma with neuroendocrine tumor characteristics: A case report

Tajima, Hidehiro; Kitagawa, Hirohisa; Shoji, Masatoshi; Watanabe, Toshifumi; Nakanuma, Shinichi; Okamoto, Koichi; Sakai, Seisho; Kinoshita, Jun; Makino, Isamu; Furukawa, Hiroyuki; Nakamura, Keishi; Hayashi, Hironori; Oyama, Katsunobu; Inokuchi, Masafumi; Nakagawara, Hisatoshi; Miyashita, Tomoharu; Itoh, Hiroshi; Takamura, Hiroyuki; Ninomiya, Itasu; Fushida, Sachio; Fujimura, Takashi; Ohta, Tetsuo; Satoh, Hirohide; Ikeda, Hiroko; Harada, Kenichi; Nakanuma, Yasuni

2014 Oncology Letters

doi:10.3892/ol.2014.1873 pmid:24944667

A 61‑year‑old female with pancreatic body cancer underwent a distal pancreatectomy. The tumor was a moderately‑ to poorly‑differentiated adenocarcinoma. Tumor growth filled the dilated main pancreatic duct (MPD) and infiltrated the surrounding area. Six months later, metastases to the left...
LitStream

Journal Article

Ectopic pancreas in the anterior mediastinum: A report of two cases and review of the literature

Zhang, Lizhi; Peng, Li‑Qing; Yu, Jian‑Qun; Yuan, Hong‑Mei; Chu, Zhi‑Gang; Zeng, Han‑Jiang; Wei, Bing

2014 Oncology Letters

doi:10.3892/ol.2014.1840 pmid:24660035

Ectopia of the pancreatic tissue is a developmental anomaly found in ~2% of all autopsies, and 70~90% of these anomalies are located in the gastrointestinal tract. Mediastinal localization of an ectopic pancreas is extremely rare. Herein, we report two cases with mediastinal ectopic pancreas...
LitStream

Journal Article

Hydroxychloroquine facilitates autophagosome formation but not degradation to suppress the proliferation of cervical cancer SiHa cells

Liu, Qingsong; Luo, Xiong Yan; Jiang, Hong Yan; Yang, Ming‑Hui Yan; Yuan, Guo‑Hua Yan; Tang, Zhong Yan; Wang, He Yan

2014 Oncology Letters

doi:10.3892/ol.2014.1879 pmid:24944668

Hydroxychloroquine (HCQ), the hydroxylated analog of chloroquine, is an antimalarial lysomotropic agent that inhibits autophagy due to lysosomal acidification, and subsequently blocks the fusion of autophagosomes with lysosomes which leads to the accumulation of autophagosomes that may accelerate...
LitStream

Journal Article

Squamous cell carcinoma arising from an unknown primary site metastasizing to the stomach: A case report

Wang, Guangyao; Chen, Ping; Shi, Lei; Zhao, Wei

2014 Oncology Letters

doi:10.3892/ol.2014.1836 pmid:24944669

Primary squamous cell carcinoma (SCC) may originate elsewhere in the body, including the head, neck, lung, bronchus, cervix uteri, esophagus and cardia, and metastasize to the stomach. In the present report, a case is presented of an SCC, which arose from an unknown primary site and metastasized...
LitStream

Journal Article

Clinicopathological findings in a case series of abdominopelvic solitary fibrous tumors

Wang, Hao; Chen, Ping; Zhao, Wei; Shi, Lei; Gu, Xuewen; Xu, Qing

2014 Oncology Letters

doi:10.3892/ol.2014.1872 pmid:24944670

Solitary fibrous tumors (SFTs) represent a rare type of soft tissue tumor. Extrathoracic SFTs (ESFTs) in the soft tissues of the abdominopelvic cavity are extremely rare. Between January 2002 and January 2013, 10 patients were identified with abdominopelvic SFTs at the Northern Jiangsu People's...
LitStream

Journal Article

Downregulation of hnRNP K by RNAi inhibits growth of human lung carcinoma cells

Tang, Fengming; Li, Weimin; Chen, Yan; Wang, Dongmei; Han, Juan; Liu, Dan

2014 Oncology Letters

doi:10.3892/ol.2014.1832 pmid:24944671

Lung cancer is one of the most common malignancies worldwide, but its pathogenesis remains unknown. The current study examined the effects of heterogeneous nuclear ribonucleoprotein K (hnRNP K)‑targeted small interfering RNA (siRNA) on the growth and apoptosis of lung cancer cells in vitro. The...
LitStream

Journal Article

Aberrant expression of redox protein Ape1 in colon cancer stem cells

Lou, Debao; Zhu, Lina; Ding, Huawei; Dai, Hai‑Yan; Zou, Gang‑Ming

2014 Oncology Letters

doi:10.3892/ol.2014.1864 pmid:24944672

Ape1 is an important redox protein, essential for specific cytokine‑induced signal transduction. Ape1 signaling is also important in regulating the growth of cancer cells, including colon cancer cells. The present study investigated whether Ape1 signaling plays a role in the regulation of colon...

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