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Mitochondria are emerging as key players in the tumorigenic process of cells
by maintaining the biosynthetic and energetic capabilities of cancer cells. It
is now evident that mitochondria are involved in the malignant transformation,
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‑associated
mortality worldwide. Hepatocarcinogenesis involves numerous interlinked factors
and processes, including the Sonic hedgehog (Shh) signaling pathway, which participates
Compared with linear RNA, circular RNAs (circRNAs) form a covalently closed
circular continuous loop and are highly conserved, stable and tissue‑specific.
In recent years, circRNAs received considerable attention in the diagnosis, classification,
Long non‑coding RNAs (lncRNAs) are RNA sequences >200 nucleotides in
length that have no protein‑coding capacity. lncRNAs serve key roles in multiple
biological processes, such as tumorigenesis and tumor progression. Taurine upregulated
1 (TUG1) is a novel...
Pancreatic cancer is a highly malignant cancer associated with high expression
levels of sonic hedgehog signaling molecule (Shh), patched 1 (Ptch1), smoothened
frizzled class receptor (Smo) and glioma‑associated oncogene family zinc finger 1
(Gli1) in the...
Anti‑CD19 chimeric antigen receptor T cell (CAR‑T) therapy has changed the
typical outcomes of relapsed/refractory B‑cell leukemia and lymphoma. However,
treatment effectiveness for patients with relapsed/refractory B‑cell non‑Hodgkin
lymphoma has been less...
The present study aimed to investigate the effects and mechanisms of STAM
binding protein‑like 1 (STAMBPL1) knockdown in the suppression of gastric cancer
activities. Pathological data and STAMBPL1 protein expression were analysed in
36 patients with gastric...
Lung cancer is one of the most widespread neoplasms worldwide. To identify
the key biomarkers in its carcinogenesis and development, the mRNA microarray
datasets GSE102287, GSE89047, GSE67061 and GSE74706 were obtained from the Gene
Expression Omnibus database....
The present study aimed to identify the novel biomarkers and underlying
molecular mechanisms of lung adenocarcinoma (LAC) to aid in its diagnosis, prognosis,
prediction, disease monitoring and emerging therapies. Data from a total of 498
LAC samples were...
Human anterior gradient proteins AGR2 and AGR3 are overexpressed in a variety
of adenocarcinomas and are often secreted in cancer patients' specimens, which
suggests a role for AGR proteins in intra and extracellular compartments. Although
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