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Cancer cells are characterized by a high glycolytic rate, which leads to
energy regeneration and anabolic metabolism; a consequence of this is the abnormal
expression of pyruvate kinase isoenzyme M2 (PKM2). Multiple studies have demonstrated
that the expression...
Estrogen is an important sex steroid hormone which serves an important role
in the regulation of a number of biological functions, including regulating bone
density, brain function, cholesterol mobilization, electrolyte balance, skin physiology,
Gastric cancer (GC) is a malignant tumor that negatively impacts human health,
which typically presents in the advanced stages of disease in the majority of
patients. Despite the development of combination chemotherapy, only a modest survival
Apoptosis repressor with caspase recruitment domain (ARC) is a potent inhibitor
of apoptosis. Under physiological conditions, ARC is abundantly expressed in terminally
differentiated cells, including cardiomyocytes, skeletal muscles and neurons.
ARC serves a...
Breast cancer is the most common malignant neoplasm in women worldwide,
and the treatment regimens currently available are far from optimal. Targeted
therapy, based on molecular typing of breast cancer, is the most precise form
of treatment, and CXC chemokine...
Liver cancer is one of the most common cancer types globally. However, the
acquisition of drug resistance limits the effectiveness of chemotherapy and commonly
results in metastasis. Therefore, an effective therapeutic approach to target...
Adoptive T cell immunotherapy with cytokine‑induced killer cells (CIKs)
has been demonstrated to prolong the survival of patients with advanced non‑small
cell lung cancer (NSCLC). The aim of the present study was to evaluate whether
the expansion of effector T...
Pancreatic carcinoma is one of the most malignant diseases and is associated
with a poor survival rate. Pituitary adenylate cyclase activating polypeptide
(PACAP) is a neuropeptide that acts on three different G protein‑coupled receptors:
the specific PAC1 and...
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney
cancer. Novel biomarkers of ccRCC may provide crucial information on tumor features
and prognosis. The present study aimed to determine whether the expression of
Hepatocellular carcinoma (HCC) is a common type of malignant tumor worldwide
with a high mortality rate. In the past 20 years, the morbidity rate of HCC has
increased. Progress has been made in the clinical diagnosis and therapy for HCC.
However, due to the...
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